Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.bmcl.2020.127472 http://scihub22266oqcxt.onion/10.1016/j.bmcl.2020.127472 32781216!7414322!32781216     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioorg+Med+Chem+Lett 2020 ; 30 (20): 127472 Nephropedia Template TP {{tp|p=32781216|t=2020. Identification of 4-anilino-6-aminoquinazoline derivatives as potential MERS-CoV inhibitors |pdf=|usr=}}{{32781216}} gab.com Text Identification of 4-anilino-6-aminoquinazoline derivatives as potential MERS-CoV inhibitors JO: Bioorg Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=32781216 #FOAvip New therapies for treating coronaviruses are urgently needed. A series of 4-anilino-6-aminoquinazoline derivatives were synthesized and evaluated to show high anti-MERS-CoV activities. N(4)-(3-Chloro-4-fluorophenyl)-N(6)-(3-methoxybenzyl)quinazoline-4,6-diamine (1) has been identified in a random screen as a hit compound for inhibiting MERS-CoV infection. Throughout optimization process, compound 20 was found to exhibit high inhibitory effect (IC(50) = 0.157 muM, SI = 25) with no cytotoxicity and moderate in vivo PK properties. Twit Text FOAVip Identification of 4-anilino-6-aminoquinazoline derivatives as potential MERS-CoV inhibitors ????Bioorg Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=32781216 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32781216 #FOAvip English Wikipedia <ref>{{Cite pmid|32781216}}</ref> Identification of 4-anilino-6-aminoquinazoline derivatives as potential MERS-CoV inhibitors #MMPMID32781216 Lee JY; Shin YS; Lee J; Kwon S; Jin YH; Jang MS; Kim S; Song JH; Kim HR; Park CM Bioorg Med Chem Lett 2020[Oct]; 30 (20): 127472 PMID32781216show ga New therapies for treating coronaviruses are urgently needed. A series of 4-anilino-6-aminoquinazoline derivatives were synthesized and evaluated to show high anti-MERS-CoV activities. N(4)-(3-Chloro-4-fluorophenyl)-N(6)-(3-methoxybenzyl)quinazoline-4,6-diamine (1) has been identified in a random screen as a hit compound for inhibiting MERS-CoV infection. Throughout optimization process, compound 20 was found to exhibit high inhibitory effect (IC(50) = 0.157 muM, SI = 25) with no cytotoxicity and moderate in vivo PK properties. |Aniline Compounds/chemical synthesis/pharmacokinetics/*pharmacology/toxicity[MESH] |Animals[MESH] |Antiviral Agents/chemical synthesis/pharmacokinetics/*pharmacology/toxicity[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Cricetulus[MESH] |Humans[MESH] |Mice[MESH] |Microbial Sensitivity Tests[MESH] |Middle East Respiratory Syndrome Coronavirus/*drug effects[MESH] |Molecular Structure[MESH] |Quinazolines/chemical synthesis/pharmacokinetics/*pharmacology/toxicity[MESH] |Rats[MESH]Identification of 4-anilino-6-aminoquinazoline derivatives as potentia(epmc).pdf DeepDyve Pubget Overpricing