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10.1093/ajhp/zxaa287 http://scihub22266oqcxt.onion/10.1093/ajhp/zxaa287 32780853!7454294!32780853     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32780853&cmd=llinks): Failed to open stream: HTTP request failed! 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Thrombolysis and use of argatroban for the treatment of massive pulmonary embolism following anticoagulation failure in a patient with COVID-19 |pdf=|usr=}}{{32780853}} gab.com Text Thrombolysis and use of argatroban for the treatment of massive pulmonary embolism following anticoagulation failure in a patient with COVID-19 JO: Am J Health Syst Pharm http://www.kidney.de/pget.php?&tw=1&pmid=32780853 #FOAvip PURPOSE: Successful use of alteplase and argatroban to treat a patient with coronavirus disease 2019 (COVID-19)-associated massive pulmonary embolism with cardiac arrest is reported. SUMMARY: This case report describes a 42-year-old male with COVID-19 who developed a massive pulmonary embolism resulting in cardiac arrest after suspected failure of low-molecular-weight heparin therapy for a deep venous thrombosis. Administration of two 50-mg doses of intravenous alteplase resulted in return of spontaneous circulation, and low-dose argatroban was used as follow-up anticoagulation therapy without complications. This is the first case report of use of argatroban in a patient with COVID-19 with cardiac arrest-associated massive pulmonary embolism after failure of previous anticoagulation efforts. CONCLUSION: Argatroban may be used as an alternate anticoagulation strategy in COVID-19 patients who fail low-molecular weight therapy. A risk versus benefit discussion should be had regarding appropriateness of therapy as well as dosing. More data is needed to understand the unique hypercoagulable condition in COVID-19 patients as well as research that further highlights the role of argatroban and bivalirudin therapy in this patient population. Twit Text FOAVip Thrombolysis and use of argatroban for the treatment of massive pulmonary embolism following anticoagulation failure in a patient with COVID-19 ????Am J Health Syst Pharm http://www.kidney.de/pget.php?&tw=1&pmid=32780853 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32780853 #FOAvip English Wikipedia <ref>{{Cite pmid|32780853}}</ref> Thrombolysis and use of argatroban for the treatment of massive pulmonary embolism following anticoagulation failure in a patient with COVID-19 #MMPMID32780853 Sagardia LM; Daniels LM Am J Health Syst Pharm 2020[Nov]; 77 (23): 1961-1964 PMID32780853show ga PURPOSE: Successful use of alteplase and argatroban to treat a patient with coronavirus disease 2019 (COVID-19)-associated massive pulmonary embolism with cardiac arrest is reported. SUMMARY: This case report describes a 42-year-old male with COVID-19 who developed a massive pulmonary embolism resulting in cardiac arrest after suspected failure of low-molecular-weight heparin therapy for a deep venous thrombosis. Administration of two 50-mg doses of intravenous alteplase resulted in return of spontaneous circulation, and low-dose argatroban was used as follow-up anticoagulation therapy without complications. This is the first case report of use of argatroban in a patient with COVID-19 with cardiac arrest-associated massive pulmonary embolism after failure of previous anticoagulation efforts. CONCLUSION: Argatroban may be used as an alternate anticoagulation strategy in COVID-19 patients who fail low-molecular weight therapy. A risk versus benefit discussion should be had regarding appropriateness of therapy as well as dosing. More data is needed to understand the unique hypercoagulable condition in COVID-19 patients as well as research that further highlights the role of argatroban and bivalirudin therapy in this patient population. |Adult[MESH] |Anticoagulants/*therapeutic use[MESH] |Arginine/analogs & derivatives[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications[MESH] |Fibrinolytic Agents/*therapeutic use[MESH] |Heart Arrest/etiology/therapy[MESH] |Heparin, Low-Molecular-Weight/therapeutic use[MESH] |Humans[MESH] |Male[MESH] |Pandemics[MESH] |Pipecolic Acids/*therapeutic use[MESH] |Pneumonia, Viral/*complications[MESH] |Pulmonary Embolism/*drug therapy/*etiology[MESH] |Sulfonamides[MESH] |Thrombolytic Therapy/*methods[MESH] |Treatment Failure[MESH]Thrombolysis and use of argatroban for the treatment of massive pulmon(epmc).pdf DeepDyve Pubget Overpricing