The microbial coinfection in COVID-19 #MMPMID32780290
Chen X; Liao B; Cheng L; Peng X; Xu X; Li Y; Hu T; Li J; Zhou X; Ren B
Appl Microbiol Biotechnol 2020[Sep]; 104 (18): 7777-7785 PMID32780290show ga
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel beta-coronavirus, is the main pathogenic agent of the rapidly spreading pneumonia called coronavirus disease 2019 (COVID-19). SARS-CoV-2 infects much more people, especially the elder population, around the world than other coronavirus, such as SARS-CoV and MERS-CoV, which is challenging current global public health system. Beyond the pathogenesis of SARS-CoV-2, microbial coinfection plays an important role in the occurrence and development of SARS-CoV-2 infection by raising the difficulties of diagnosis, treatment, prognosis of COVID-19, and even increasing the disease symptom and mortality. We summarize the coinfection of virus, bacteria and fungi with SARS-CoV-2, their effects on COVID-19, the reasons of coinfection, and the diagnosis to emphasize the importance of microbial coinfection in COVID-19. KEY POINTS: * Microbial coinfection is a nonnegligible factor in COVID-19. * Microbial coinfection exacerbates the processes of the occurrence, development and prognosis of COVID-19, and the difficulties of clinical diagnosis and treatment. * Different virus, bacteria, and fungi contributed to the coinfection with SARS-CoV-2.
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Appl+Microbiol+Biotechnol 2020 ; 104 (18): 7777-7785
