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A human circulating immune cell landscape in aging and COVID-19 #MMPMID32780218
Zheng Y; Liu X; Le W; Xie L; Li H; Wen W; Wang S; Ma S; Huang Z; Ye J; Shi W; Ye Y; Liu Z; Song M; Zhang W; Han JJ; Belmonte JCI; Xiao C; Qu J; Wang H; Liu GH; Su W
Protein Cell 2020[Oct]; 11 (10): 740-770 PMID32780218show ga
Age-associated changes in immune cells have been linked to an increased risk for infection. However, a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking. Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19. We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector, cytotoxic, exhausted and regulatory cells, along with increased late natural killer cells, age-associated B cells, inflammatory monocytes and age-associated dendritic cells. In addition, the expression of genes, which were implicated in coronavirus susceptibility, was upregulated in a cell subtype-specific manner with age. Notably, COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senescence. Therefore, these findings suggest that a dysregulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly.
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Protein+Cell 2020 ; 11 (10): 740-770
