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10.1111/febs.15481 http://scihub22266oqcxt.onion/10.1111/febs.15481 32779891!7405290!32779891     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+J 2020 ; 287 (17): 3681-3688 Nephropedia Template TP {{tp|p=32779891|t=2020. Sympathetic activation: a potential link between comorbidities and COVID-19 |pdf=|usr=}}{{32779891}} gab.com Text Sympathetic activation: a potential link between comorbidities and COVID-19 JO: FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=32779891 #FOAvip In coronavirus disease 2019 (COVID-19), higher morbidity and mortality are associated with age, male gender, and comorbidities, such as chronic lung diseases, cardiovascular pathologies, hypertension, kidney diseases, diabetes mellitus, and obesity. All of the above conditions are characterized by increased sympathetic discharge, which may exert significant detrimental effects on COVID-19 patients, through actions on the lungs, heart, blood vessels, kidneys, metabolism, and/or immune system. Furthermore, COVID-19 may also increase sympathetic discharge, through changes in blood gases (chronic intermittent hypoxia, hyperpnea), angiotensin-converting enzyme (ACE)1/ACE2 imbalance, immune/inflammatory factors, or emotional distress. Nevertheless, the potential role of the sympathetic nervous system has not yet been considered in the pathophysiology of COVID-19. In our opinion, sympathetic overactivation could represent a so-far undervalued mechanism for a vicious circle between COVID-19 and comorbidities. Twit Text FOAVip Sympathetic activation: a potential link between comorbidities and COVID-19 ????FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=32779891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32779891 #FOAvip English Wikipedia <ref>{{Cite pmid|32779891}}</ref> Sympathetic activation: a potential link between comorbidities and COVID-19 #MMPMID32779891 Porzionato A; Emmi A; Barbon S; Boscolo-Berto R; Stecco C; Stocco E; Macchi V; De Caro R FEBS J 2020[Sep]; 287 (17): 3681-3688 PMID32779891show ga In coronavirus disease 2019 (COVID-19), higher morbidity and mortality are associated with age, male gender, and comorbidities, such as chronic lung diseases, cardiovascular pathologies, hypertension, kidney diseases, diabetes mellitus, and obesity. All of the above conditions are characterized by increased sympathetic discharge, which may exert significant detrimental effects on COVID-19 patients, through actions on the lungs, heart, blood vessels, kidneys, metabolism, and/or immune system. Furthermore, COVID-19 may also increase sympathetic discharge, through changes in blood gases (chronic intermittent hypoxia, hyperpnea), angiotensin-converting enzyme (ACE)1/ACE2 imbalance, immune/inflammatory factors, or emotional distress. Nevertheless, the potential role of the sympathetic nervous system has not yet been considered in the pathophysiology of COVID-19. In our opinion, sympathetic overactivation could represent a so-far undervalued mechanism for a vicious circle between COVID-19 and comorbidities. |COVID-19/*metabolism/mortality/pathology/virology[MESH] |Comorbidity[MESH] |Coronary Disease/*metabolism/mortality/pathology/virology[MESH] |Diabetes Mellitus/*metabolism/mortality/pathology/virology[MESH] |Female[MESH] |Humans[MESH] |Hypertension/*metabolism/mortality/pathology/virology[MESH] |Kidney Failure, Chronic/*metabolism/mortality/pathology/virology[MESH] |Male[MESH] |Obesity/*metabolism/mortality/pathology/virology[MESH] |Respiratory Insufficiency/*metabolism/mortality/pathology/virology[MESH] |SARS-CoV-2/metabolism/pathogenicity[MESH] |Severity of Illness Index[MESH] |Sex Factors[MESH] |Survival Analysis[MESH]Sympathetic activation: a potential link between comorbidities and COV(epmc).pdf DeepDyve Pubget Overpricing