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10.1002/ptr.6767 http://scihub22266oqcxt.onion/10.1002/ptr.6767 32779813!7404680!32779813     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Phytother+Res 2020 ; 34 (12): 3200-3210 Nephropedia Template TP {{tp|p=32779813|t=2020. Rugosic acid A, derived from Rosa rugosa Thunb , is novel inhibitory agent for NF-kappaB and IL-6/STAT3 axis in acute lung injury model |pdf=|usr=}}{{32779813}} gab.com Text Rugosic acid A, derived from Rosa rugosa Thunb , is novel inhibitory agent for NF-kappaB and IL-6/STAT3 axis in acute lung injury model JO: Phytother Res http://www.kidney.de/pget.php?&tw=1&pmid=32779813 #FOAvip Rosa rugosa Thunb., is as a medicinal plant known for anti-diabetic, and anti-inflammatory activities. However, the specific active compounds responsible for the individual pharmacological effects of in R. rugosa extract (95% EtOH) remain unknown. Here, we hypothesized that terpenoid structure, the most abundant constituents in R. rugosa extract, are responsible for its anti-inflammatory activity. We investigated the phytochemical substituents (compounds 1-13) and newly purified 11-methoxy polisin A, and 13-methoxy bisaborosaol F using NMR and ESI-MS and to screened their effects on NO production in LPS-induced macrophages. Rugosic acid A (RA) induced to ameliorate NO production, iNOS, and pro-inflammatory cytokines associated with the NF-kappaB. And, RA suppressed IL-6 secretion and IL-6-mediated STAT3 activation in LPS-mediated inflammation. In addition, RA was evaluated in LPS-mediated acute lung injury (ALI) model similar to acute pneumonia. Our results suggested that RA was suppressed to translocate nuclear NF-kappaB and IL-6-mediated STAT3 activation. Finally, RA led to amelioration of ALI by decreasing myeloperoxidase (MPO) and inhibiting phosphorylation of NF-kappaB and STAT3. Our group originally found that R. rugosa extract had new methoxy compounds and RA may be alternative natural agent for acute pneumonia similar to severe acute respiratory syndrome by coronavirus. Twit Text FOAVip Rugosic acid A, derived from Rosa rugosa Thunb , is novel inhibitory agent for NF-kappaB and IL-6/STAT3 axis in acute lung injury model ????Phytother Res http://www.kidney.de/pget.php?&tw=1&pmid=32779813 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32779813 #FOAvip English Wikipedia <ref>{{Cite pmid|32779813}}</ref> Rugosic acid A, derived from Rosa rugosa Thunb , is novel inhibitory agent for NF-kappaB and IL-6/STAT3 axis in acute lung injury model #MMPMID32779813 Kim KH; Park YJ; Jang HJ; Lee SJ; Lee S; Yun BS; Lee SW; Rho MC Phytother Res 2020[Dec]; 34 (12): 3200-3210 PMID32779813show ga Rosa rugosa Thunb., is as a medicinal plant known for anti-diabetic, and anti-inflammatory activities. However, the specific active compounds responsible for the individual pharmacological effects of in R. rugosa extract (95% EtOH) remain unknown. Here, we hypothesized that terpenoid structure, the most abundant constituents in R. rugosa extract, are responsible for its anti-inflammatory activity. We investigated the phytochemical substituents (compounds 1-13) and newly purified 11-methoxy polisin A, and 13-methoxy bisaborosaol F using NMR and ESI-MS and to screened their effects on NO production in LPS-induced macrophages. Rugosic acid A (RA) induced to ameliorate NO production, iNOS, and pro-inflammatory cytokines associated with the NF-kappaB. And, RA suppressed IL-6 secretion and IL-6-mediated STAT3 activation in LPS-mediated inflammation. In addition, RA was evaluated in LPS-mediated acute lung injury (ALI) model similar to acute pneumonia. Our results suggested that RA was suppressed to translocate nuclear NF-kappaB and IL-6-mediated STAT3 activation. Finally, RA led to amelioration of ALI by decreasing myeloperoxidase (MPO) and inhibiting phosphorylation of NF-kappaB and STAT3. Our group originally found that R. rugosa extract had new methoxy compounds and RA may be alternative natural agent for acute pneumonia similar to severe acute respiratory syndrome by coronavirus. |*Rosa[MESH] |Acute Lung Injury/chemically induced/*drug therapy/immunology[MESH] |Animals[MESH] |Anti-Inflammatory Agents/pharmacology/*therapeutic use[MESH] |Cell Line[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Humans[MESH] |Interleukin-6/*antagonists & inhibitors[MESH] |Lipopolysaccharides[MESH] |Mice, Inbred BALB C[MESH] |NF-kappa B/*antagonists & inhibitors[MESH]Rugosic acid A, derived from Rosa rugosa Thunb , is novel inhibitory a(epmc).pdf DeepDyve Pubget Overpricing