COVID-19 and Vitamin D: A lesson from the skin #MMPMID32779213
Slominski RM; Stefan J; Athar M; Holick MF; Jetten AM; Raman C; Slominski AT
Exp Dermatol 2020[Sep]; 29 (9): 885-890 PMID32779213show ga
The negative outcomes of COVID-19 diseases respiratory distress (ARDS) and the damage to other organs are secondary to a "cytokine storm" and to the attendant oxidative stress. Active hydroxyl forms of vitamin D are anti-inflammatory, induce antioxidative responses, and stimulate innate immunity against infectious agents. These properties are shared by calcitriol and the CYP11A1-generated non-calcemic hydroxyderivatives. They inhibit the production of pro-inflammatory cytokines, downregulate NF-kappaBeta, show inverse agonism on RORgamma and counteract oxidative stress through the activation of NRF-2. Therefore, a direct delivery of hydroxyderivatives of vitamin D deserves consideration in the treatment of COVID-19 or ARDS of different aetiology. We also recommend treatment of COVID-19 patients with high-dose vitamin D since populations most vulnerable to this disease are likely vitamin D deficient and patients are already under supervision in the clinics. We hypothesize that different routes of delivery (oral and parenteral) will have different impact on the final outcome.
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Exp+Dermatol 2020 ; 29 (9): 885-890
