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10.1002/jcph.1729

http://scihub22266oqcxt.onion/10.1002/jcph.1729
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32779201!7436618!32779201
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suck abstract from ncbi


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pmid32779201      J+Clin+Pharmacol 2020 ; 60 (10): 1275-1293
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  • Immunomodulatory Therapeutic Proteins in COVID-19: Current Clinical Development and Clinical Pharmacology Considerations #MMPMID32779201
  • Ji P; Chen J; Golding A; Nikolov NP; Saluja B; Ren YR; Sahajwalla CG
  • J Clin Pharmacol 2020[Oct]; 60 (10): 1275-1293 PMID32779201show ga
  • The coronavirus disease 2019 (COVID-19) pandemic caused by infection with SARS-CoV-2 has led to more than 600 000 deaths worldwide. Patients with severe disease often experience acute respiratory distress characterized by upregulation of multiple cytokines. Immunomodulatory biological therapies are being evaluated in clinical trials for the management of the systemic inflammatory response and pulmonary complications in patients with advanced stages of COVID-19. In this review, we summarize the clinical pharmacology considerations in the development of immunomodulatory therapeutic proteins for mitigating the heightened inflammatory response identified in COVID-19.
  • |Betacoronavirus/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/*drug therapy/epidemiology/immunology[MESH]
  • |Drug Development[MESH]
  • |Humans[MESH]
  • |Immunologic Factors/*administration & dosage/pharmacology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/epidemiology/immunology[MESH]
  • |Proteins/*administration & dosage/immunology/pharmacology[MESH]


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