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10.1111/ajo.13204

http://scihub22266oqcxt.onion/10.1111/ajo.13204
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32779193!7436616!32779193
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suck abstract from ncbi


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pmid32779193      Aust+N+Z+J+Obstet+Gynaecol 2020 ; 60 (5): 640-659
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  • COVID-19 and pregnancy: A review of clinical characteristics, obstetric outcomes and vertical transmission #MMPMID32779193
  • Pettirosso E; Giles M; Cole S; Rees M
  • Aust N Z J Obstet Gynaecol 2020[Oct]; 60 (5): 640-659 PMID32779193show ga
  • BACKGROUND: Since its emergence in December 2019, COVID-19 has spread to over 210 countries, with an estimated mortality rate of 3-4%. Little is understood about its effects during pregnancy. AIMS: To describe the current understanding of COVID-19 illness in pregnant women, to describe obstetric outcomes and to identify gaps in the existing knowledge. METHODS: Medline Ovid, EMBASE, World Health Organization COVID-19 research database and Cochrane COVID-19 in pregnancy spreadsheet were accessed on 18/4, 18/5 and 23/5 2020. Articles were screened via Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The following were excluded: reviews, opinion pieces, guidelines, articles pertaining solely to other viruses, single case reports. RESULTS: Sixty articles were included in this review. Some pregnant participants may have been included in multiple publications, as admission dates overlap for reports from the same hospital. However, a total of 1287 confirmed SARS-CoV-2 positive pregnant cases are reported. Where universal testing was undertaken, asymptomatic infection occurred in 43.5-92% of cases. In the cohort studies, severe and critical COVID-19 illness rates approximated those of the non-pregnant population. Eight maternal deaths, six neonatal deaths, seven stillbirths and five miscarriages were reported. Nineteen neonates were SARS-CoV-2 positive, confirmed by reverse transcription polymerase chain reaction of nasopharyngeal swabs. [Correction added on 2 September 2020, after first online publication: the number of neonates indicated in the preceding sentence has been corrected from 'Thirteen' to 'Nineteen'.] CONCLUSIONS: Where universal screening was conducted, SARS-CoV-2 infection in pregnancy was often asymptomatic. Severe and critical disease rates approximate those in the general population. Vertical transmission is possible; however, it is unclear whether SARS-CoV-2 positive neonates were infected in utero, intrapartum or postpartum. Future work should assess risks of congenital syndromes and adverse perinatal outcomes where infection occurs in early and mid-pregnancy.
  • |Abortion, Spontaneous/epidemiology[MESH]
  • |Adult[MESH]
  • |Australia[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques/*methods[MESH]
  • |Coronavirus Infections/diagnosis/epidemiology/*transmission[MESH]
  • |Databases, Factual[MESH]
  • |Delivery, Obstetric/methods[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant Mortality/*trends[MESH]
  • |Infant, Newborn[MESH]
  • |Infection Control/methods[MESH]
  • |Maternal Mortality/trends[MESH]
  • |Pandemics/*prevention & control/statistics & numerical data[MESH]
  • |Pneumonia, Viral/epidemiology/*transmission[MESH]
  • |Pregnancy[MESH]
  • |Pregnancy Complications, Infectious/*diagnosis/epidemiology[MESH]
  • |Pregnancy Trimesters[MESH]
  • |Premature Birth/epidemiology[MESH]
  • |Retrospective Studies[MESH]
  • |World Health Organization[MESH]


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