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10.1007/s12020-020-02444-9 http://scihub22266oqcxt.onion/10.1007/s12020-020-02444-9 32779091!7417102!32779091     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Endocrine 2020 ; 70 (3): 441-453 Nephropedia Template TP {{tp|p=32779091|t=2020. Hypothesized mechanisms explaining poor prognosis in type 2 diabetes patients with COVID-19: a review |pdf=|usr=}}{{32779091}} gab.com Text Hypothesized mechanisms explaining poor prognosis in type 2 diabetes patients with COVID-19: a review JO: Endocrine http://www.kidney.de/pget.php?&tw=1&pmid=32779091 #FOAvip PURPOSE: Epidemiological data suggest that comorbid patients, mostly those with type 2 diabetes (T2D), are predisposed to poor prognosis in Coronavirus disease 2019 (COVID-19), leading to serious healthcare concerns. The aim of the present manuscript is to review the main relevant mechanisms possibly contributing to worsen the clinical course of COVID-19 in T2D. RESULTS: Poor glucose control, high glycaemic variability and diabetes-related comorbidities at baseline, particularly cardiovascular diseases and obesity, contribute in worsening the prognosis in the above-mentioned cluster of patients. Moreover, both a lower efficient innate immune system response and cytokine dysregulation predispose patients with T2D to impaired viral clearance and more serious pulmonary and systemic inflammation once the SARS-CoV-2 infection occurred. Inconclusive data are currently available for specifically indicate or contraindicate concurrent medications for managing T2D and its comorbidities in infected patients. CONCLUSIONS: T2D individuals should be considered as more vulnerable to COVID-19 than general population, and thus require adequate advices about hygienic tips to protect themselves during the pandemic. A careful management of glucose levels and diabetes-related comorbidities remains essential for avoiding further complications, and patient monitoring during the pandemic should be performed also at distance by means of telemedicine. Further studies are needed to clarify whether medications normally used for managing T2D and its associated comorbidities could have a protective or detrimental effect on COVID-19 clinical course. Twit Text FOAVip Hypothesized mechanisms explaining poor prognosis in type 2 diabetes patients with COVID-19: a review ????Endocrine http://www.kidney.de/pget.php?&tw=1&pmid=32779091 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32779091 #FOAvip English Wikipedia <ref>{{Cite pmid|32779091}}</ref> Hypothesized mechanisms explaining poor prognosis in type 2 diabetes patients with COVID-19: a review #MMPMID32779091 Lisco G; De Tullio A; Giagulli VA; Guastamacchia E; De Pergola G; Triggiani V Endocrine 2020[Dec]; 70 (3): 441-453 PMID32779091show ga PURPOSE: Epidemiological data suggest that comorbid patients, mostly those with type 2 diabetes (T2D), are predisposed to poor prognosis in Coronavirus disease 2019 (COVID-19), leading to serious healthcare concerns. The aim of the present manuscript is to review the main relevant mechanisms possibly contributing to worsen the clinical course of COVID-19 in T2D. RESULTS: Poor glucose control, high glycaemic variability and diabetes-related comorbidities at baseline, particularly cardiovascular diseases and obesity, contribute in worsening the prognosis in the above-mentioned cluster of patients. Moreover, both a lower efficient innate immune system response and cytokine dysregulation predispose patients with T2D to impaired viral clearance and more serious pulmonary and systemic inflammation once the SARS-CoV-2 infection occurred. Inconclusive data are currently available for specifically indicate or contraindicate concurrent medications for managing T2D and its comorbidities in infected patients. CONCLUSIONS: T2D individuals should be considered as more vulnerable to COVID-19 than general population, and thus require adequate advices about hygienic tips to protect themselves during the pandemic. A careful management of glucose levels and diabetes-related comorbidities remains essential for avoiding further complications, and patient monitoring during the pandemic should be performed also at distance by means of telemedicine. Further studies are needed to clarify whether medications normally used for managing T2D and its associated comorbidities could have a protective or detrimental effect on COVID-19 clinical course. |Betacoronavirus/physiology[MESH] |COVID-19[MESH] |Cardiovascular Diseases/complications/epidemiology[MESH] |Comorbidity[MESH] |Coronavirus Infections/*complications/*diagnosis/epidemiology/pathology[MESH] |Diabetes Mellitus, Type 2/*complications/*diagnosis/epidemiology/pathology[MESH] |Disease Progression[MESH] |Humans[MESH] |Mortality[MESH] |Obesity/complications/epidemiology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/*diagnosis/epidemiology/pathology[MESH] |Prognosis[MESH] |Risk Factors[MESH] |SARS-CoV-2[MESH]Hypothesized mechanisms explaining poor prognosis in type 2 diabetes p(epmc).pdf DeepDyve Pubget Overpricing