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10.1093/bib/bbaa173 http://scihub22266oqcxt.onion/10.1093/bib/bbaa173 32778874!7454314!32778874     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brief+Bioinform 2021 ; 22 (2): 1175-1196 Nephropedia Template TP {{tp|p=32778874|t=2021. Pathogenetic profiling of COVID-19 and SARS-like viruses |pdf=|usr=}}{{32778874}} gab.com Text Pathogenetic profiling of COVID-19 and SARS-like viruses JO: Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=32778874 #FOAvip The novel coronavirus (2019-nCoV) has recently emerged, causing COVID-19 outbreaks and significant societal/global disruption. Importantly, COVID-19 infection resembles SARS-like complications. However, the lack of knowledge about the underlying genetic mechanisms of COVID-19 warrants the development of prospective control measures. In this study, we employed whole-genome alignment and digital DNA-DNA hybridization analyses to assess genomic linkage between 2019-nCoV and other coronaviruses. To understand the pathogenetic behavior of 2019-nCoV, we compared gene expression datasets of viral infections closest to 2019-nCoV with four COVID-19 clinical presentations followed by functional enrichment of shared dysregulated genes. Potential chemical antagonists were also identified using protein-chemical interaction analysis. Based on phylogram analysis, the 2019-nCoV was found genetically closest to SARS-CoVs. In addition, we identified 562 upregulated and 738 downregulated genes (adj. P </= 0.05) with SARS-CoV infection. Among the dysregulated genes, SARS-CoV shared </=19 upregulated and </=22 downregulated genes with each of different COVID-19 complications. Notably, upregulation of BCL6 and PFKFB3 genes was common to SARS-CoV, pneumonia and severe acute respiratory syndrome, while they shared CRIP2, NSG1 and TNFRSF21 genes in downregulation. Besides, 14 genes were common to different SARS-CoV comorbidities that might influence COVID-19 disease. We also observed similarities in pathways that can lead to COVID-19 and SARS-CoV diseases. Finally, protein-chemical interactions suggest cyclosporine, resveratrol and quercetin as promising drug candidates against COVID-19 as well as other SARS-like viral infections. The pathogenetic analyses, along with identified biomarkers, signaling pathways and chemical antagonists, could prove useful for novel drug development in the fight against the current global 2019-nCoV pandemic. Twit Text FOAVip Pathogenetic profiling of COVID-19 and SARS-like viruses ????Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=32778874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32778874 #FOAvip English Wikipedia <ref>{{Cite pmid|32778874}}</ref> Pathogenetic profiling of COVID-19 and SARS-like viruses #MMPMID32778874 Nain Z; Rana HK; Lio P; Islam SMS; Summers MA; Moni MA Brief Bioinform 2021[Mar]; 22 (2): 1175-1196 PMID32778874show ga The novel coronavirus (2019-nCoV) has recently emerged, causing COVID-19 outbreaks and significant societal/global disruption. Importantly, COVID-19 infection resembles SARS-like complications. However, the lack of knowledge about the underlying genetic mechanisms of COVID-19 warrants the development of prospective control measures. In this study, we employed whole-genome alignment and digital DNA-DNA hybridization analyses to assess genomic linkage between 2019-nCoV and other coronaviruses. To understand the pathogenetic behavior of 2019-nCoV, we compared gene expression datasets of viral infections closest to 2019-nCoV with four COVID-19 clinical presentations followed by functional enrichment of shared dysregulated genes. Potential chemical antagonists were also identified using protein-chemical interaction analysis. Based on phylogram analysis, the 2019-nCoV was found genetically closest to SARS-CoVs. In addition, we identified 562 upregulated and 738 downregulated genes (adj. P |Antiviral Agents/therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/complications/*virology[MESH] |Case-Control Studies[MESH] |Comorbidity[MESH] |Genome, Viral[MESH] |Humans[MESH] |MicroRNAs/metabolism[MESH] |SARS-CoV-2/*pathogenicity[MESH] |Severe acute respiratory syndrome-related coronavirus/genetics/*pathogenicity[MESH]Pathogenetic profiling of COVID-19 and SARS-like viruses (epmc).pdf DeepDyve Pubget Overpricing