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10.1503/cmaj.200990

http://scihub22266oqcxt.onion/10.1503/cmaj.200990
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32778573!7513947!32778573
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suck abstract from ncbi


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pmid32778573      CMAJ 2020 ; 192 (37): E1053-E1064
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  • Projected effects of nonpharmaceutical public health interventions to prevent resurgence of SARS-CoV-2 transmission in Canada #MMPMID32778573
  • Ng V; Fazil A; Waddell LA; Bancej C; Turgeon P; Otten A; Atchessi N; Ogden NH
  • CMAJ 2020[Sep]; 192 (37): E1053-E1064 PMID32778573show ga
  • BACKGROUND: Continual efforts to eliminate community transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will be needed to prevent additional waves of infection. We explored the impact of nonpharmaceutical interventions on projected SARS-CoV-2 transmission in Canada. METHODS: We developed an age-structured agent-based model of the Canadian population simulating the impact of current and projected levels of public health interventions on SARS-CoV-2 transmission. Interventions included case detection and isolation, contact tracing and quarantine, physical distancing and community closures, evaluated alone and in combination. RESULTS: Without any interventions, 64.6% (95% credible interval [CrI] 63.9%-65.0%) of Canadians will be infected with SARS-CoV-2 (total attack rate) and 3.6% (95% CrI 2.4%-3.8%) of those infected and symptomatic will die. If case detection and contact tracing continued at baseline levels without maintained physical distancing and reimplementation of restrictive measures, this combination brought the total attack rate to 56.1% (95% CrI 0.05%-57.1%), but it dropped to 0.4% (95% CrI 0.03%-23.5%) with enhanced case detection and contact tracing. Combining the latter scenario with maintained physical distancing reduced the total attack rate to 0.2% (95% CrI 0.03%-1.7%) and was the only scenario that consistently kept hospital and intensive care unit bed use under capacity, prevented nearly all deaths and eliminated the epidemic. Extending school closures had minimal effects but did reduce transmission in schools; however, extending closures of workplaces and mixed-age venues markedly reduced attack rates and usually or always eliminated the epidemic under any scenario. INTERPRETATION: Controlling SARS-CoV-2 transmission will depend on enhancing and maintaining interventions at both the community and individual levels. Without such interventions, a resurgent epidemic will occur, with the risk of overwhelming our health care systems.
  • |*Contact Tracing[MESH]
  • |*Patient Isolation[MESH]
  • |*Public Health[MESH]
  • |*Quarantine[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Asymptomatic Infections/epidemiology[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Canada/epidemiology[MESH]
  • |Child[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Communicable Disease Control[MESH]
  • |Computer Simulation[MESH]
  • |Coronavirus Infections/diagnosis/epidemiology/*prevention & control/transmission[MESH]
  • |Humans[MESH]
  • |Middle Aged[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/diagnosis/epidemiology/*prevention & control/transmission[MESH]
  • |SARS-CoV-2[MESH]


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  • suck abstract from ncbi

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