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10.1186/s13014-020-01631-2

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suck abstract from ncbi


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pmid32778174      Radiat+Oncol 2020 ; 15 (1): 191
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  • Two months of radiation oncology in the heart of Italian "red zone" during COVID-19 pandemic: paving a safe path over thin ice #MMPMID32778174
  • Buglione M; Spiazzi L; Guerini AE; Barbera F; Pasinetti N; Pegurri L; Triggiani L; Tomasini D; Greco D; Costantino G; Bragaglio A; Bonometti N; Liccioli M; Mascaro L; Alongi F; Magrini SM
  • Radiat Oncol 2020[Aug]; 15 (1): 191 PMID32778174show ga
  • BACKGROUND: Coronavirus Disease 2019 (COVID-19) pandemic had an overwhelming impact on healthcare worldwide. Outstandingly, the aftermath on neoplastic patients is still largely unknown, and only isolated cases of COVID-19 during radiotherapy have been published. We will report the two-months experience of our Department, set in Lombardy "red-zone". METHODS: Data of 402 cancer patients undergoing active treatment from February 24 to April 24, 2020 were retrospectively reviewed; several indicators of the Department functioning were also analyzed. RESULTS: Dedicated measures allowed an overall limited reduction of the workload. Decrease of radiotherapy treatment number reached 17%, while the number of administration of systemic treatment and follow up evaluations kept constant. Conversely, new treatment planning faced substantial decline. Considering the patients, infection rate was 3.23% (13/402) and mortality 1.24% (5/402). Median age of COVID-19 patients was 69.7 years, the large majority were male and smokers (84.6%); lung cancer was the most common tumor type (61.5%), 84.6% of subjects were stage III-IV and 92.3% had comorbidities. Remarkably, 92.3% of the cases were detected before March 24. Globally, only 2.5% of ongoing treatments were suspended due to suspect or confirmed COVID-19 and 46.2% of positive patients carried on radiotherapy without interruption. Considering only the last month, infection rate among patients undergoing treatment precipitated to 0.43% (1/232) and no new contagions were reported within our staff. CONCLUSIONS: Although mortality rate in COVID-19 cancer patients is elevated, our results support the feasibility and safety of continuing anticancer treatment during SARS-Cov-2 pandemic by endorsing consistent preventive measures.
  • |*Betacoronavirus[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*epidemiology/mortality/prevention & control[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Italy/epidemiology[MESH]
  • |Male[MESH]
  • |Neoplasms/*radiotherapy[MESH]
  • |Pandemics/prevention & control[MESH]
  • |Pneumonia, Viral/*epidemiology/mortality/prevention & control[MESH]
  • |Radiation Oncology[MESH]
  • |Retrospective Studies[MESH]


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