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10.1111/ajt.16252 http://scihub22266oqcxt.onion/10.1111/ajt.16252 32777178!7436473!32777178     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transplant 2020 ; 20 (11): 3210-3215 Nephropedia Template TP {{tp|p=32777178|t=2020. Immune monitoring facilitates the clinical decision in multifocal COVID-19 of a pancreas-kidney transplant patient |pdf=|usr=}}{{32777178}} gab.com Text Immune monitoring facilitates the clinical decision in multifocal COVID-19 of a pancreas-kidney transplant patient JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=32777178 #FOAvip The optimal management in transplant recipients with coronavirus disease 2019 (COVID-19) remains uncertain. The main concern is the ability of immunosuppressed patients to generate sufficient immunity for antiviral protection. Here, we report on immune monitoring facilitating a successful outcome of severe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated pneumonia, meningoencephalitis, gastroenteritis, and acute kidney and pancreas graft failure in a pancreas-kidney transplant recipient. Despite the very low numbers of circulating B, NK, and T cells identified in follow-up, a strong SARS-CoV-2 reactive T cell response was observed. Importantly, we detected T cells reactive to Spike, Membrane, and Nucleocapsid proteins of SARS-CoV-2 with majority of T cells showing polyfunctional proinflammatory Th1 phenotype at all analyzed time points. Antibodies against Spike protein were also detected with increasing titers in follow-up. Neutralization tests confirmed their antiviral protection. A correlation between cellular and humoral immunity was observed underscoring the specificity of demonstrated data. We conclude that analyzing the kinetics of nonspecific and SARS-CoV-2-reactive cellular and humoral immunity can facilitate the clinical decision on immunosuppression adjustment and allow successful outcome as demonstrated in the current clinical case. Although the antiviral protection of the detected SARS-CoV-2-reactive T cells requires further evaluation, our data prove an ability mounting a strong SARS-CoV-2-reactive T cell response with functional capacity in immunosuppressed patients. Twit Text FOAVip Immune monitoring facilitates the clinical decision in multifocal COVID-19 of a pancreas-kidney transplant patient ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=32777178 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32777178 #FOAvip English Wikipedia <ref>{{Cite pmid|32777178}}</ref> Immune monitoring facilitates the clinical decision in multifocal COVID-19 of a pancreas-kidney transplant patient #MMPMID32777178 Babel N; Anft M; Blazquez-Navarro A; Doevelaar AAN; Seibert FS; Bauer F; Rohn BJ; Hoelzer B; Thieme CJ; Roch T; Meister TL; Pfaender S; Steinmann E; Dittmer U; Schenker P; Amann K; Viebahn R; Stervbo U; Westhoff TH Am J Transplant 2020[Nov]; 20 (11): 3210-3215 PMID32777178show ga The optimal management in transplant recipients with coronavirus disease 2019 (COVID-19) remains uncertain. The main concern is the ability of immunosuppressed patients to generate sufficient immunity for antiviral protection. Here, we report on immune monitoring facilitating a successful outcome of severe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated pneumonia, meningoencephalitis, gastroenteritis, and acute kidney and pancreas graft failure in a pancreas-kidney transplant recipient. Despite the very low numbers of circulating B, NK, and T cells identified in follow-up, a strong SARS-CoV-2 reactive T cell response was observed. Importantly, we detected T cells reactive to Spike, Membrane, and Nucleocapsid proteins of SARS-CoV-2 with majority of T cells showing polyfunctional proinflammatory Th1 phenotype at all analyzed time points. Antibodies against Spike protein were also detected with increasing titers in follow-up. Neutralization tests confirmed their antiviral protection. A correlation between cellular and humoral immunity was observed underscoring the specificity of demonstrated data. We conclude that analyzing the kinetics of nonspecific and SARS-CoV-2-reactive cellular and humoral immunity can facilitate the clinical decision on immunosuppression adjustment and allow successful outcome as demonstrated in the current clinical case. Although the antiviral protection of the detected SARS-CoV-2-reactive T cells requires further evaluation, our data prove an ability mounting a strong SARS-CoV-2-reactive T cell response with functional capacity in immunosuppressed patients. |*Immunity, Humoral[MESH] |*Kidney Transplantation[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19/*epidemiology/virology[MESH] |Clinical Decision-Making[MESH] |Comorbidity[MESH] |Graft Rejection/epidemiology/immunology[MESH] |Humans[MESH] |Immunocompromised Host[MESH] |Monitoring, Immunologic/*methods[MESH] |Pancreas Transplantation/*methods[MESH] |Pandemics[MESH]Immune monitoring facilitates the clinical decision in multifocal COVI(epmc).pdf DeepDyve Pubget Overpricing