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10.1177/0300060520933810

http://scihub22266oqcxt.onion/10.1177/0300060520933810
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suck abstract from ncbi


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pmid32776805      J+Int+Med+Res 2020 ; 48 (8): 300060520933810
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  • Disparate effects of methicillin-resistant Staphylococcus aureus infection on renal function in IgA-dominant infection-associated glomerulonephritis and menstrual toxic shock syndrome: a case report and literature review #MMPMID32776805
  • Zhang Y; Wang HB; Chu B; Zhao HZ; Li H; Zhou HM; Wang T
  • J Int Med Res 2020[Aug]; 48 (8): 300060520933810 PMID32776805show ga
  • The sudden outbreak of severe acute respiratory syndrome coronavirus 2 pneumonia posed a significant challenge to medical professionals because treatment of critically ill patients requires the efforts of a multidisciplinary team. To highlight this principle, we examined acute kidney injury (AKI) in IgA-dominant infection-associated glomerulonephritis (GN) and menstrual toxic shock syndrome (mTSS). Both GN and mTSS are rare diseases caused by staphylococcal infection, and renal function is frequently impaired. The resulting AKIs are disparate pathological entities driven by distinct immune mechanisms. We begin by describing the case of a diabetic man with pyopneumothorax following methicillin-resistant Staphylococcus aureus (MRSA). He had endocapillary proliferative GN with in situ IgA-dominant immune-complex formation in the mesangium accompanied by complement C3 deposition in the glomerular capillary wall. By contrast, acute tubular necrosis was observed in a case of mTSS; the patient's immune response was stimulated differently by MRSA enterotoxin and exotoxin resulting in aberrant IgA deposition, complement activation, and insufficient antibody production. As a multidisciplinary communication covering the fields of nephrology, immunology, and pathology, this report may help clinicians to understand these distinct renal lesions and make optimal therapeutic decisions expeditiously.
  • |Acute Kidney Injury/microbiology/*pathology[MESH]
  • |Adolescent[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Complement Activation/immunology[MESH]
  • |Coronavirus Infections/pathology[MESH]
  • |Enterotoxins/metabolism[MESH]
  • |Female[MESH]
  • |Glomerulonephritis, IGA/microbiology/*pathology[MESH]
  • |Humans[MESH]
  • |Immunoglobulin A/*immunology[MESH]
  • |Kidney/pathology[MESH]
  • |Male[MESH]
  • |Menstruation Disturbances/microbiology/*pathology[MESH]
  • |Methicillin-Resistant Staphylococcus aureus/isolation & purification[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/pathology[MESH]
  • |Pneumothorax/microbiology/pathology[MESH]
  • |SARS-CoV-2[MESH]
  • |Shock, Septic/microbiology/*pathology[MESH]


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