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10.1002/jcp.29997 http://scihub22266oqcxt.onion/10.1002/jcp.29997 32776569!7818487!32776569     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Physiol 2021 ; 236 (3): 1712-1729 Nephropedia Template TP {{tp|p=32776569|t=2021. Molecular characteristics and physiological roles of Na(+) -K(+) -Cl(-) cotransporter 2 |pdf=|usr=}}{{32776569}} gab.com Text Molecular characteristics and physiological roles of Na(+) -K(+) -Cl(-) cotransporter 2 JO: J Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32776569 #FOAvip Na(+) -K(+) -Cl(-) cotransporter 2 (NKCC2; SLC12A1) is an integral membrane protein that comes as three splice variants and mediates the cotranslocation of Na(+) , K(+) , and Cl(-) ions through the apical membrane of the thick ascending loop of Henle (TALH). In doing so, and through the involvement of other ion transport systems, it allows this nephron segment to reclaim a large fraction of the ultrafiltered Na(+) , Cl(-) , Ca(2+) , Mg(2)(+) , and HCO(3)(-) loads. The functional relevance of NKCC2 in human is illustrated by the many abnormalities that result from the inactivation of this transport system through the use of loop diuretics or in the setting of inherited disorders. The following presentation aims at discussing the physiological roles and molecular characteristics of Na(+) -K(+) -Cl(-) cotransport in the TALH and those of the individual NKCC2 splice variants more specifically. Many of the historical and recent data that have emerged from the experiments conducted will be outlined and their larger meaning will also be placed into perspective with the aid of various hypotheses. Twit Text FOAVip Molecular characteristics and physiological roles of Na(+) -K(+) -Cl(-) cotransporter 2 ????J Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32776569 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32776569 #FOAvip English Wikipedia <ref>{{Cite pmid|32776569}}</ref> Molecular characteristics and physiological roles of Na(+) -K(+) -Cl(-) cotransporter 2 #MMPMID32776569 Marcoux AA; Tremblay LE; Slimani S; Fiola MJ; Mac-Way F; Garneau AP; Isenring P J Cell Physiol 2021[Mar]; 236 (3): 1712-1729 PMID32776569show ga Na(+) -K(+) -Cl(-) cotransporter 2 (NKCC2; SLC12A1) is an integral membrane protein that comes as three splice variants and mediates the cotranslocation of Na(+) , K(+) , and Cl(-) ions through the apical membrane of the thick ascending loop of Henle (TALH). In doing so, and through the involvement of other ion transport systems, it allows this nephron segment to reclaim a large fraction of the ultrafiltered Na(+) , Cl(-) , Ca(2+) , Mg(2)(+) , and HCO(3)(-) loads. The functional relevance of NKCC2 in human is illustrated by the many abnormalities that result from the inactivation of this transport system through the use of loop diuretics or in the setting of inherited disorders. The following presentation aims at discussing the physiological roles and molecular characteristics of Na(+) -K(+) -Cl(-) cotransport in the TALH and those of the individual NKCC2 splice variants more specifically. Many of the historical and recent data that have emerged from the experiments conducted will be outlined and their larger meaning will also be placed into perspective with the aid of various hypotheses. |Alternative Splicing/genetics[MESH] |Amino Acid Sequence[MESH] |Animals[MESH] |Humans[MESH] |Ion Transport[MESH] |Loop of Henle/metabolism[MESH] |Models, Biological[MESH]Molecular characteristics and physiological roles of Na(+) -K(+) -Cl(-(epmc).pdf DeepDyve Pubget Overpricing