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10.1016/j.xkme.2020.05.005

http://scihub22266oqcxt.onion/10.1016/j.xkme.2020.05.005
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32775990!7406850!32775990
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suck abstract from ncbi


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pmid32775990      Kidney+Med 2020 ; 2 (4): 493-497
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  • COVID-19-Associated Collapsing Focal Segmental Glomerulosclerosis: A Report of 2 Cases #MMPMID32775990
  • Sharma Y; Nasr SH; Larsen CP; Kemper A; Ormsby AH; Williamson SR
  • Kidney Med 2020[Jul]; 2 (4): 493-497 PMID32775990show ga
  • Collapsing glomerulopathy is an aggressive form of focal segmental glomerulosclerosis with diverse causes. The presence of the apolipoprotein L1 (APOL1) high-risk genotype is a major risk factor for collapsing glomerulopathy in African Americans. Coronavirus disease 2019 (COVID-19) is an emerging pandemic with predominant respiratory manifestations. However, kidney involvement is being frequently noted and is associated with higher mortality. Currently, kidney pathology data for COVID-19 are scant and mostly come from postmortem findings. We report 2 African American patients who developed acute kidney injury and proteinuria in temporal association with COVID-19 infection. Kidney biopsy specimens showed collapsing glomerulopathy, endothelial tubuloreticular inclusions, and acute tubular injury, without evidence by electron microscopy or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in situ hybridization of viral infection of kidney cells. Both patients had the APOL1 high-risk genotype. We propose that collapsing glomerulopathy represents a novel manifestation of COVID-19 infection, especially in people of African descent with APOL1 risk alleles.
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