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10.1186/s12948-020-00129-2 http://scihub22266oqcxt.onion/10.1186/s12948-020-00129-2 32774170!7402393!32774170     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32774170.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Mol+Allergy 2020 ; 18 (ä): 14 Nephropedia Template TP {{tp|p=32774170|t=2020. A gendered magnifying glass on COVID-19 |pdf=|usr=}}{{32774170}} gab.com Text A gendered magnifying glass on COVID-19 JO: Clin Mol Allergy http://www.kidney.de/pget.php?&tw=1&pmid=32774170 #FOAvip COVID-19 pandemia is affecting Countries worldwide with a gendered death excess as being a male represents, especially in the 50-69 years age group, an unfavourable factor. Females are constitutionally prone to defend themselves against pathogens with a stronger efficiency than males. As a fact, several genes involved into the regulation of the innate and adaptive immune response are strategically placed on the X-chromosome and, among them, pathogen-related receptors (PRRs), such as Toll-like receptor 7, suitable to recognize ssRNAs and trigger a gendered successful anti-viral fight. On the other hand, a more regulated IL-6 production and a more contained inflammation after the encounter of a pathogen supply score points in favour of the female sex in the view that an abnormal and exaggerated cytokine release does represent the hallmark of the deathful SARS-CoV-2 infection. The sex-prevalent expression of the attachment and permissive molecules ACE2 and TMPRSS2 further supports the concept of a male-oriented vulnerability. In this review, the possible role of biological and immunological sex differences into the higher morbidity and mortality of SARS-CoV-2 between females and males are discussed. Twit Text FOAVip A gendered magnifying glass on COVID-19 ????Clin Mol Allergy http://www.kidney.de/pget.php?&tw=1&pmid=32774170 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32774170 #FOAvip English Wikipedia <ref>{{Cite pmid|32774170}}</ref> A gendered magnifying glass on COVID-19 #MMPMID32774170 Salvati L; Biagioni B; Vivarelli E; Parronchi P Clin Mol Allergy 2020[]; 18 (ä): 14 PMID32774170show ga COVID-19 pandemia is affecting Countries worldwide with a gendered death excess as being a male represents, especially in the 50-69 years age group, an unfavourable factor. Females are constitutionally prone to defend themselves against pathogens with a stronger efficiency than males. As a fact, several genes involved into the regulation of the innate and adaptive immune response are strategically placed on the X-chromosome and, among them, pathogen-related receptors (PRRs), such as Toll-like receptor 7, suitable to recognize ssRNAs and trigger a gendered successful anti-viral fight. On the other hand, a more regulated IL-6 production and a more contained inflammation after the encounter of a pathogen supply score points in favour of the female sex in the view that an abnormal and exaggerated cytokine release does represent the hallmark of the deathful SARS-CoV-2 infection. The sex-prevalent expression of the attachment and permissive molecules ACE2 and TMPRSS2 further supports the concept of a male-oriented vulnerability. In this review, the possible role of biological and immunological sex differences into the higher morbidity and mortality of SARS-CoV-2 between females and males are discussed. äA gendered magnifying glass on COVID-19 (epmc).pdf DeepDyve Pubget Overpricing