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10.6026/97320630016288 http://scihub22266oqcxt.onion/10.6026/97320630016288 32773986!7392088!32773986     free     free     free       Bioinformation 2020 ; 16 (4): 288-292 Nephropedia Template TP {{tp|p=32773986|t=2020. Towards Neuro-CoViD-19 |pdf=|usr=}}{{32773986}} gab.com Text Towards Neuro-CoViD-19 JO: Bioinformation http://www.kidney.de/pget.php?&tw=1&pmid=32773986 #FOAvip CoViD-19 is the current pandemic caused by the Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2). Infection by SARS-CoV-2 occurs via the binding of its S protein to the angiotensin-converting enzyme-2 receptor (ACE2-R). S binding to ACE2-R leads to a drop in ACE2, a homolog of angiotensin converting enzyme (ACE). In the central nervous system (CNS), ACE mediates neuroinflammation, neurodegeneration and neurotoxicity responsible for several CNS disorders. ACE2 counteracts the damaging effects of ACE on CNS neurons. SARS-CoV-2 can directly access the CNS via the circulation or via cranial nerve I and the olfactory bulb. Inactivation of ACE2 following binding of SARS-CoV-2 S protein to ACE2-R in situ might blunt ACE2-moderating effects upon ACE CNS neurotoxicity and neurodegeneration. Here, we propose a neurobiological mechanism directly involving SARS-CoV-2 binding to ACE2-R in the etiology of putative Neuro-CoViD-19. Twit Text FOAVip Towards Neuro-CoViD-19 ????Bioinformation http://www.kidney.de/pget.php?&tw=1&pmid=32773986 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32773986 #FOAvip English Wikipedia <ref>{{Cite pmid|32773986}}</ref> Towards Neuro-CoViD-19 #MMPMID32773986 Chiappelli F Bioinformation 2020[]; 16 (4): 288-292 PMID32773986show ga CoViD-19 is the current pandemic caused by the Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2). Infection by SARS-CoV-2 occurs via the binding of its S protein to the angiotensin-converting enzyme-2 receptor (ACE2-R). S binding to ACE2-R leads to a drop in ACE2, a homolog of angiotensin converting enzyme (ACE). In the central nervous system (CNS), ACE mediates neuroinflammation, neurodegeneration and neurotoxicity responsible for several CNS disorders. ACE2 counteracts the damaging effects of ACE on CNS neurons. SARS-CoV-2 can directly access the CNS via the circulation or via cranial nerve I and the olfactory bulb. Inactivation of ACE2 following binding of SARS-CoV-2 S protein to ACE2-R in situ might blunt ACE2-moderating effects upon ACE CNS neurotoxicity and neurodegeneration. Here, we propose a neurobiological mechanism directly involving SARS-CoV-2 binding to ACE2-R in the etiology of putative Neuro-CoViD-19. äTowards Neuro-CoViD-19 (epmc).pdf DeepDyve Pubget Overpricing