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10.24272/j.issn.2095-8137.2020.202 http://scihub22266oqcxt.onion/10.24272/j.issn.2095-8137.2020.202 32772513!7475018!32772513     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Zool+Res 2020 ; 41 (5): 503-516 Nephropedia Template TP {{tp|p=32772513|t=2020. Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques |pdf=|usr=}}{{32772513}} gab.com Text Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques JO: Zool Res http://www.kidney.de/pget.php?&tw=1&pmid=32772513 #FOAvip As of June 2020, Coronavirus Disease 2019 (COVID-19) has killed an estimated 440 000 people worldwide, 74% of whom were aged >/=65 years, making age the most significant risk factor for death caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To examine the effect of age on death, we established a SARS-CoV-2 infection model in Chinese rhesus macaques ( Macaca mulatta) of varied ages. Results indicated that infected young macaques manifested impaired respiratory function, active viral replication, severe lung damage, and infiltration of CD11b (+) and CD8 (+) cells in lungs at one-week post infection (wpi), but also recovered rapidly at 2 wpi. In contrast, aged macaques demonstrated delayed immune responses with a more severe cytokine storm, increased infiltration of CD11b (+) cells, and persistent infiltration of CD8 (+) cells in the lungs at 2 wpi. In addition, peripheral blood T cells from aged macaques showed greater inflammation and chemotaxis, but weaker antiviral functions than that in cells from young macaques. Thus, the delayed but more severe cytokine storm and higher immune cell infiltration may explain the poorer prognosis of older aged patients suffering SARS-CoV-2 infection. Twit Text FOAVip Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques ????Zool Res http://www.kidney.de/pget.php?&tw=1&pmid=32772513 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32772513 #FOAvip English Wikipedia <ref>{{Cite pmid|32772513}}</ref> Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques #MMPMID32772513 Song TZ; Zheng HY; Han JB; Jin L; Yang X; Liu FL; Luo RH; Tian RR; Cai HR; Feng XL; Liu C; Li MH; Zheng YT Zool Res 2020[Sep]; 41 (5): 503-516 PMID32772513show ga As of June 2020, Coronavirus Disease 2019 (COVID-19) has killed an estimated 440 000 people worldwide, 74% of whom were aged >/=65 years, making age the most significant risk factor for death caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To examine the effect of age on death, we established a SARS-CoV-2 infection model in Chinese rhesus macaques ( Macaca mulatta) of varied ages. Results indicated that infected young macaques manifested impaired respiratory function, active viral replication, severe lung damage, and infiltration of CD11b (+) and CD8 (+) cells in lungs at one-week post infection (wpi), but also recovered rapidly at 2 wpi. In contrast, aged macaques demonstrated delayed immune responses with a more severe cytokine storm, increased infiltration of CD11b (+) cells, and persistent infiltration of CD8 (+) cells in the lungs at 2 wpi. In addition, peripheral blood T cells from aged macaques showed greater inflammation and chemotaxis, but weaker antiviral functions than that in cells from young macaques. Thus, the delayed but more severe cytokine storm and higher immune cell infiltration may explain the poorer prognosis of older aged patients suffering SARS-CoV-2 infection. |Age Factors[MESH] |Aging/*immunology/metabolism[MESH] |Animals[MESH] |Betacoronavirus/*immunology/physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/veterinary/virology[MESH] |Cytokines/*immunology/metabolism[MESH] |Inflammation/immunology/veterinary/virology[MESH] |Lung/immunology/pathology/virology[MESH] |Macaca mulatta/*immunology/virology[MESH] |Monkey Diseases/immunology/virology[MESH] |Pandemics/veterinary[MESH] |Pneumonia, Viral/*immunology/veterinary/virology[MESH] |SARS-CoV-2[MESH] |Severe Acute Respiratory Syndrome/immunology/veterinary/virology[MESH] |T-Lymphocytes/*immunology/metabolism/pathology[MESH] |Viral Load/immunology/veterinary[MESH]Delayed severe cytokine storm and immune cell infiltration in SARS-CoV(epmc).pdf DeepDyve Pubget Overpricing