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10.1007/s10571-020-00938-8

http://scihub22266oqcxt.onion/10.1007/s10571-020-00938-8
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32772307!7415199!32772307
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suck abstract from ncbi


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pmid32772307      Cell+Mol+Neurobiol 2022 ; 42 (3): 489-500
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  • Coronavirus Disease 2019 (COVID-19) and Its Neuroinvasive Capacity: Is It Time for Melatonin? #MMPMID32772307
  • Romero A; Ramos E; Lopez-Munoz F; Gil-Martin E; Escames G; Reiter RJ
  • Cell Mol Neurobiol 2022[Apr]; 42 (3): 489-500 PMID32772307show ga
  • The world faces an exceptional new public health concern caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), subsequently termed the coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO). Although the clinical symptoms mostly have been characterized, the scientific community still doesn t know how SARS-CoV-2 successfully reaches and spreads throughout the central nervous system (CNS) inducing brain damage. The recent detection of SARS-CoV-2 in the cerebrospinal fluid (CSF) and in frontal lobe sections from postmortem examination has confirmed the presence of the virus in neural tissue. This finding reveals a new direction in the search for a neurotherapeutic strategy in the COVID-19 patients with underlying diseases. Here, we discuss the COVID-19 outbreak in a neuroinvasiveness context and suggest the therapeutic use of high doses of melatonin, which may favorably modulate the immune response and neuroinflammation caused by SARS-CoV-2. However, clinical trials elucidating the efficacy of melatonin in the prevention and clinical management in the COVID-19 patients should be actively encouraged.
  • |*COVID-19 Drug Treatment[MESH]
  • |Animals[MESH]
  • |Brain/drug effects/pathology/virology[MESH]
  • |COVID-19/complications/pathology[MESH]
  • |Central Nervous System Agents/pharmacology/therapeutic use[MESH]
  • |Central Nervous System Viral Diseases/drug therapy/pathology[MESH]
  • |Central Nervous System/drug effects/pathology/*virology[MESH]
  • |Humans[MESH]
  • |Melatonin/pharmacology/*therapeutic use[MESH]
  • |Neuroprotective Agents/pharmacology/therapeutic use[MESH]


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