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10.1093/cid/ciaa1163 http://scihub22266oqcxt.onion/10.1093/cid/ciaa1163 32772069!7454332!32772069     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Infect+Dis 2021 ; 72 (9): e367-e372 Nephropedia Template TP {{tp|p=32772069|t=2021. Clinical Outcomes Associated With Methylprednisolone in Mechanically Ventilated Patients With COVID-19 |pdf=|usr=}}{{32772069}} gab.com Text Clinical Outcomes Associated With Methylprednisolone in Mechanically Ventilated Patients With COVID-19 JO: Clin Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32772069 #FOAvip BACKGROUND: The efficacy and safety of methylprednisolone in mechanically ventilated patients with acute respiratory distress syndrome resulting from coronavirus disease 2019 (COVID-19) are unclear. In this study, we evaluated the association between use of methylprednisolone and key clinical outcomes. METHODS: Clinical outcomes associated with the use of methylprednisolone were assessed in an unmatched, case-control study; a subset of patients also underwent propensity-score matching. Patients were admitted between 1 March and 12 April, 2020. The primary outcome was ventilator-free days by 28 days after admission. Secondary outcomes included extubation, mortality, discharge, positive cultures, and hyperglycemia. RESULTS: A total of 117 patients met inclusion criteria. Propensity matching yielded a cohort of 42 well-matched pairs. Groups were similar except for hydroxychloroquine and azithromycin use, which were more common in patients who did not receive methylprednisolone. Mean ventilator-free days were significantly higher in patients treated with methylprednisolone (6.21 +/- 7.45 vs 3.14 +/- 6.22; P = .044). The probability of extubation was also increased in patients receiving methylprednisolone (45% vs 21%; P = .021), and there were no significant differences in mortality (19% vs 36%; P = .087). In a multivariable linear regression analysis, only methylprednisolone use was associated with a higher number of ventilator-free days (P = .045). The incidence of positive cultures and hyperglycemia were similar between groups. CONCLUSIONS: Methylprednisolone was associated with increased ventilator-free days and higher probability of extubation in a propensity-score matched cohort. Randomized, controlled studies are needed to further define methylprednisolone use in patients with COVID-19. Twit Text FOAVip Clinical Outcomes Associated With Methylprednisolone in Mechanically Ventilated Patients With COVID-19 ????Clin Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32772069 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32772069 #FOAvip English Wikipedia <ref>{{Cite pmid|32772069}}</ref> Clinical Outcomes Associated With Methylprednisolone in Mechanically Ventilated Patients With COVID-19 #MMPMID32772069 Nelson BC; Laracy J; Shoucri S; Dietz D; Zucker J; Patel N; Sobieszczyk ME; Kubin CJ; Gomez-Simmonds A Clin Infect Dis 2021[May]; 72 (9): e367-e372 PMID32772069show ga BACKGROUND: The efficacy and safety of methylprednisolone in mechanically ventilated patients with acute respiratory distress syndrome resulting from coronavirus disease 2019 (COVID-19) are unclear. In this study, we evaluated the association between use of methylprednisolone and key clinical outcomes. METHODS: Clinical outcomes associated with the use of methylprednisolone were assessed in an unmatched, case-control study; a subset of patients also underwent propensity-score matching. Patients were admitted between 1 March and 12 April, 2020. The primary outcome was ventilator-free days by 28 days after admission. Secondary outcomes included extubation, mortality, discharge, positive cultures, and hyperglycemia. RESULTS: A total of 117 patients met inclusion criteria. Propensity matching yielded a cohort of 42 well-matched pairs. Groups were similar except for hydroxychloroquine and azithromycin use, which were more common in patients who did not receive methylprednisolone. Mean ventilator-free days were significantly higher in patients treated with methylprednisolone (6.21 +/- 7.45 vs 3.14 +/- 6.22; P = .044). The probability of extubation was also increased in patients receiving methylprednisolone (45% vs 21%; P = .021), and there were no significant differences in mortality (19% vs 36%; P = .087). In a multivariable linear regression analysis, only methylprednisolone use was associated with a higher number of ventilator-free days (P = .045). The incidence of positive cultures and hyperglycemia were similar between groups. CONCLUSIONS: Methylprednisolone was associated with increased ventilator-free days and higher probability of extubation in a propensity-score matched cohort. Randomized, controlled studies are needed to further define methylprednisolone use in patients with COVID-19. |*COVID-19[MESH] |*Methylprednisolone/therapeutic use[MESH] |Case-Control Studies[MESH] |Humans[MESH] |Respiration, Artificial[MESH] |SARS-CoV-2[MESH]Clinical Outcomes Associated With Methylprednisolone in Mechanically V(epmc).pdf DeepDyve Pubget Overpricing