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10.1016/j.intimp.2020.106861

http://scihub22266oqcxt.onion/10.1016/j.intimp.2020.106861
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32771946!7391978!32771946
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suck abstract from ncbi


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pmid32771946      Int+Immunopharmacol 2020 ; 88 (ä): 106861
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  • Serological detection of 2019-nCoV respond to the epidemic: A useful complement to nucleic acid testing #MMPMID32771946
  • Zhang J; Zhang X; Liu J; Ban Y; Li N; Wu Y; Liu Y; Ye R; Liu J; Li X; Li L; Qin X; Zheng R
  • Int Immunopharmacol 2020[Nov]; 88 (ä): 106861 PMID32771946show ga
  • Corona Virus Disease 2019 (COVID-19) has spread rapidly to more than 215 countries, with over 11.91 million reported cases and more than 540,000 deaths. Rapid diagnosis remains a bottleneck for containing the epidemic. We used an automated chemiluminescent immunoassay to detect serum IgM and IgG antibodies to the 2019-nCoV in 742 subjects, so as to observe the dynamic process of antibody production in COVID-19 disease and seroepidemiology in different populations. Patients with COVID-19 were reactive (positive) for specific antibodies within 3-15 days after onset of symptoms. Specific IgM and IgG levels increased with the progression of the disease. The areas under the receiver operating characteristic curves for IgM and IgG were 0.984 and 1.000, respectively. This antibody detection assay had good sensitivity and specificity. The understanding of the dynamic serological changes of COVID-19 patients and the seroepidemiological situation of the population will be helpful to further control the epidemic of COVID-19.
  • |*Clinical Laboratory Techniques[MESH]
  • |*Reverse Transcriptase Polymerase Chain Reaction[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |Betacoronavirus/immunology[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Coronavirus Infections/*blood/diagnosis/immunology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/*blood[MESH]
  • |Immunoglobulin M/*blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood/immunology[MESH]
  • |SARS-CoV-2[MESH]
  • |Sensitivity and Specificity[MESH]
  • |Seroepidemiologic Studies[MESH]
  • |Severity of Illness Index[MESH]


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