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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Arch+Gerontol+Geriatr 2020 ; 91 (ä): 104204 Nephropedia Template TP
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Clinical course and prognostic factors of COVID-19 infection in an elderly hospitalized population #MMPMID32771883
Mostaza JM; Garcia-Iglesias F; Gonzalez-Alegre T; Blanco F; Varas M; Hernandez-Blanco C; Hontanon V; Jaras-Hernandez MJ; Martinez-Prieto M; Menendez-Saldana A; Cachan ML; Estirado E; Lahoz C
Arch Gerontol Geriatr 2020[Nov]; 91 (ä): 104204 PMID32771883show ga
INTRODUCTION: Older subjects have a higher risk of COVID-19 infection and a greater mortality. However, there is a lack of studies evaluating the characteristics of this infection at advanced age. PATIENTS AND METHODS: We studied 404 patients >/= 75 years (mean age 85.2?+/-?5.3 years, 55 % males), with PCR-confirmed COVID-19 infection, attended in two hospitals in Madrid (Spain). Patients were followed-up until they were discharged from the hospital or until death. RESULTS: Symptoms started 2-7 days before admission, and consisted of fever (64 %), cough (59 %), and dyspnea (57 %). A total of 145 patients (35.9 %) died a median of 9 days after hospitalization. In logistic regression analysis, predictive factors of death were age (OR 1.086; 1.015-1.161 per year, p?=?0.016), heart rate (1.040; 1.018-1.061 per beat, p?0.0001), a decline in renal function during hospitalization (OR 7.270; 2.586-20.441, p?0.0001) and worsening dyspnea during hospitalization (OR 73.616; 30.642-176.857, p?0.0001). Factors predicting survival were a female sex (OR 0.271; 0.128-0.575, p?=?0.001), previous treatment with RAAS inhibitors (OR 0.459; 0.222-0.949, p?=?0.036), a higher oxygen saturation at admission (OR 0.901; 0.842-0.963 per percentage point increase, p?=?0.002), and a greater platelet count (OR 0.995; 0.991-0.999 per 10(6)/L, p?=?0.025). CONCLUSION: Elderly patients with COVID-19 infection have a similar clinical course to younger individuals. Previous treatment with RAAS inhibitors, and demographic, clinical and laboratory data influence prognosis.