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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nature 1988 ; 331 (6151): 86-8 Nephropedia Template TP
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ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells #MMPMID3277059
Makgoba MW; Sanders ME; Ginther Luce GE; Dustin ML; Springer TA; Clark EA; Mannoni P; Shaw S
Nature 1988[Jan]; 331 (6151): 86-8 PMID3277059show ga
Cell-cell adhesion is essential for many immunological functions. The LFA-1 molecule, a member of a superfamily of adhesion molecules, participates in adhesion which is critical to the function of each of the three major subsets of leukocytes: lymphocytes, monocytes and granulocytes. Putative LFA-1 ligands have been identified functionally in different laboratories using three different monoclonal antibodies that inhibit LFA-1-mediated leukocyte adhesion in particular model systems; however, there may be more than one LFA-1 ligand. We have directly compared the three relevant monoclonal antibodies, and show that each binds to the same molecule, intercellular-adhesion molecule-1 (ICAM-1). Most important, B, T and myeloid cells adhere specifically to purified ICAM-1-coated surfaces; such adhesion has distinctive requirements for Mg2+ and Ca2+. This constitutes biochemical evidence that ICAM-1 functions as a ligand for LFA-1-dependent adhesion by a variety of leukocytes.
Nature 1988 ; 331 (6151): 86-8
