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10.1097/MD.0000000000021380

http://scihub22266oqcxt.onion/10.1097/MD.0000000000021380
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32769869!7593076!32769869
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suck abstract from ncbi


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pmid32769869      Medicine+(Baltimore) 2020 ; 99 (32): e21380
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  • Antiplatelet/anticoagulant agents for preventing thrombosis events in patients with severe COVID-19: A protocol for systematic review and meta-analysis #MMPMID32769869
  • Li Y; Xu Y; Shi P; Zhu Y; Hu W; Chen C
  • Medicine (Baltimore) 2020[Aug]; 99 (32): e21380 PMID32769869show ga
  • BACKGROUND: On March 11, 2020, World Health Organization announced that severe acute respiratory syndrome coronavirus 2 caused COVID-19 was a global pandemic. COVID-19 is associated with venous thromboembolism including deep vein thrombosis and pulmonary embolism. To further identify the current role of antiplatelet/anticoagulant therapy in the prophylaxis and treatment of COVID-19 patients is important. METHODS: We will conduct a systematic review based on searches of major databases (eg, Pubmed, Web of Science, EMBASE, CENTRAL, MEDLINE, SCI-EXPANDED, CPCI-S, CBM, CNKI, and Wanfang Database) and clinical trial registries from inception to present without limitations of language and publication status. All published randomized control trials, quasi-randomized trials, retrospective and observational studies related to prophylactic antiplatelet/anticoagulant for severe COVID-19 will be included. Primary outcome includes incident acute thrombosis events. Second outcome is the incidence and severity of adverse effects. Full-text screening, data extraction and quality assessment will be conducted by 2 reviewers independently. The reporting quality, risk of bias, sensitivity analysis and subgroup analysis will be performed to ensure the reliability of our findings by other 2 researchers. The statistical analysis will be performed by RevMan V.5.3 software and Stata V.12.0 software. RESULTS: The result of this systematic review will provide valid advice and consultation for clinicians on the management of prophylactic antiplatelet/anticoagulant for severe COVID-19 patients. CONCLUSION: This systematic review will provide evidence for prophylactic antiplatelet/anticoagulant of severe COVID-19 patients. PROSPERO REGISTRATION: CRD42020186928.
  • |*Hospital Mortality[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Anticoagulants/*administration & dosage[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/diagnosis/*epidemiology/prevention & control[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Meta-Analysis as Topic[MESH]
  • |Middle Aged[MESH]
  • |Pandemics/prevention & control/*statistics & numerical data[MESH]
  • |Platelet Aggregation Inhibitors/*administration & dosage[MESH]
  • |Pneumonia, Viral/diagnosis/*epidemiology/prevention & control[MESH]
  • |Primary Prevention/methods[MESH]
  • |Prognosis[MESH]
  • |Research Design[MESH]
  • |Risk Assessment[MESH]
  • |Severe Acute Respiratory Syndrome/epidemiology/prevention & control[MESH]
  • |Survival Analysis[MESH]
  • |Systematic Review as Topic[MESH]
  • |Thrombosis/*epidemiology/prevention & control[MESH]


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