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10.4103/sjg.SJG_239_20 http://scihub22266oqcxt.onion/10.4103/sjg.SJG_239_20 32769260!7739989!32769260     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Saudi+J+Gastroenterol 2020 ; 26 (5): 272-278 Nephropedia Template TP {{tp|p=32769260|t=2020. Abnormal liver-related biomarkers in COVID-19 patients and the role of prealbumin |pdf=|usr=}}{{32769260}} gab.com Text Abnormal liver-related biomarkers in COVID-19 patients and the role of prealbumin JO: Saudi J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=32769260 #FOAvip BACKGROUND/AIMS: We aimed to evaluate the distribution of abnormal liver-related biomarkers in patients with coronavirus disease (COVID-19) and explore the prognostic value of elevated liver enzymes and abnormal liver synthetic capacity with regards to patient mortality. PATIENTS AND METHODS: This retrospective observational study included 80 laboratory-confirmed COVID-19 cases. Data were collected from the electronic medical record system by a trained team of physicians. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TB), albumin, and prealbumin levels at admission and on day 7 after admission were collected. The primary outcome of the current study was patient mortality. RESULTS: Abnormal ALT, AST, TB, albumin, and prealbumin levels were observed in 11 (13.8%), 15 (18.8%), 5 (6.3%), 22 (27.5%), and 31 (38.8%) patients, respectively. Male gender correlated with elevated ALT and AST levels (p = 0.027 and 0.036, respectively). Higher levels of AST and lower levels of albumin and prealbumin were associated with patient mortality (p = 0.009, 0.002, and 0.003, respectively). Multivariate Cox regression analysis identified patient age (p = 0.013, HR 1.108) and prealbumin levels (p = 0.015, HR 0.986) as independent predictors for patient mortality. However, changes in liver-related biomarkers were not associated with poor outcome in multivariate analysis (p > 0.05). CONCLUSIONS: Abnormalities in albumin and prealbumin levels are common among COVID-19 patients and hypoprealbuminemia independently predicts adverse outcome and should be carefully considered in clinical practice. Moreover, changes in liver-related biomarkers is not a salient feature of COVID-19. Twit Text FOAVip Abnormal liver-related biomarkers in COVID-19 patients and the role of prealbumin ????Saudi J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=32769260 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32769260 #FOAvip English Wikipedia <ref>{{Cite pmid|32769260}}</ref> Abnormal liver-related biomarkers in COVID-19 patients and the role of prealbumin #MMPMID32769260 Li T; Guo Y; Zhuang X; Huang L; Zhang X; Wei F; Yang B Saudi J Gastroenterol 2020[Sep]; 26 (5): 272-278 PMID32769260show ga BACKGROUND/AIMS: We aimed to evaluate the distribution of abnormal liver-related biomarkers in patients with coronavirus disease (COVID-19) and explore the prognostic value of elevated liver enzymes and abnormal liver synthetic capacity with regards to patient mortality. PATIENTS AND METHODS: This retrospective observational study included 80 laboratory-confirmed COVID-19 cases. Data were collected from the electronic medical record system by a trained team of physicians. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TB), albumin, and prealbumin levels at admission and on day 7 after admission were collected. The primary outcome of the current study was patient mortality. RESULTS: Abnormal ALT, AST, TB, albumin, and prealbumin levels were observed in 11 (13.8%), 15 (18.8%), 5 (6.3%), 22 (27.5%), and 31 (38.8%) patients, respectively. Male gender correlated with elevated ALT and AST levels (p = 0.027 and 0.036, respectively). Higher levels of AST and lower levels of albumin and prealbumin were associated with patient mortality (p = 0.009, 0.002, and 0.003, respectively). Multivariate Cox regression analysis identified patient age (p = 0.013, HR 1.108) and prealbumin levels (p = 0.015, HR 0.986) as independent predictors for patient mortality. However, changes in liver-related biomarkers were not associated with poor outcome in multivariate analysis (p > 0.05). CONCLUSIONS: Abnormalities in albumin and prealbumin levels are common among COVID-19 patients and hypoprealbuminemia independently predicts adverse outcome and should be carefully considered in clinical practice. Moreover, changes in liver-related biomarkers is not a salient feature of COVID-19. |*Betacoronavirus[MESH] |Aged[MESH] |Alanine Transaminase/blood[MESH] |Aspartate Aminotransferases/blood[MESH] |Bilirubin/blood[MESH] |Biomarkers/blood[MESH] |COVID-19[MESH] |Comorbidity[MESH] |Coronavirus Infections/*blood/epidemiology[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Humans[MESH] |Liver Diseases/*blood/epidemiology[MESH] |Liver Function Tests[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*blood/epidemiology[MESH] |Prealbumin/*metabolism[MESH] |Prognosis[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]Abnormal liver-related biomarkers in COVID-19 patients and the role of(epmc).pdf DeepDyve Pubget Overpricing