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10.1136/annrheumdis-2020-217984

http://scihub22266oqcxt.onion/10.1136/annrheumdis-2020-217984
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32769150!ä!32769150

suck abstract from ncbi


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pmid32769150      Ann+Rheum+Dis 2020 ; 79 (11): 1393-1399
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  • Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases #MMPMID32769150
  • Freites Nunez DD; Leon L; Mucientes A; Rodriguez-Rodriguez L; Font Urgelles J; Madrid Garcia A; Colomer JI; Jover JA; Fernandez-Gutierrez B; Abasolo L
  • Ann Rheum Dis 2020[Nov]; 79 (11): 1393-1399 PMID32769150show ga
  • OBJECTIVES: To describe patients with autoimmune inflammatory rheumatic diseases (AIRD) who had COVID-19 disease; to compare patients who required hospital admission with those who did not and assess risk factors for hospital admission related to COVID-19. METHODS: An observational longitudinal study was conducted during the pandemic peak of severe acute respiratory syndrome coronavirus 2 (1 March 2020 to 24 April). All patients attended at the rheumatology outpatient clinic of a tertiary hospital in Madrid, Spain with a medical diagnosis of AIRD and with symptomatic COVID-19 were included. The main outcome was hospital admission related to COVID-19. The covariates were sociodemographic, clinical and treatments. We ran a multivariable logistic regression model to assess risk factors for the hospital admission. RESULTS: The study population included 123 patients with AIRD and COVID-19. Of these, 54 patients required hospital admission related to COVID-19. The mean age on admission was 69.7 (15.7) years, and the median time from onset of symptoms to hospital admission was 5 (3-10) days. The median length of stay was 9 (6-14) days. A total of 12 patients died (22%) during admission. Compared with outpatients, the factors independently associated with hospital admission were older age (OR: 1.08; p=0.00) and autoimmune systemic condition (vs chronic inflammatory arthritis) (OR: 3.55; p=0.01). No statistically significant findings for exposure to disease-modifying antirheumatic drugs were found in the final model. CONCLUSION: Our results suggest that age and having a systemic autoimmune condition increased the risk of hospital admission, whereas disease-modifying antirheumatic drugs were not associated with hospital admission.
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Ambulatory Care[MESH]
  • |Antirheumatic Agents/therapeutic use[MESH]
  • |Arthritis, Rheumatoid/drug therapy/epidemiology[MESH]
  • |Autoimmune Diseases/drug therapy/*epidemiology[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*therapy[MESH]
  • |Diabetes Mellitus/epidemiology[MESH]
  • |Female[MESH]
  • |Glucocorticoids/therapeutic use[MESH]
  • |Heart Diseases/epidemiology[MESH]
  • |Hospitalization/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Hypertension/epidemiology[MESH]
  • |Length of Stay/statistics & numerical data[MESH]
  • |Longitudinal Studies[MESH]
  • |Lung Diseases/epidemiology[MESH]
  • |Lupus Erythematosus, Systemic/drug therapy/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Mixed Connective Tissue Disease/drug therapy/epidemiology[MESH]
  • |Multivariate Analysis[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*therapy[MESH]
  • |Polymyalgia Rheumatica/drug therapy/epidemiology[MESH]
  • |Protective Factors[MESH]
  • |Rheumatic Diseases/drug therapy/*epidemiology[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Sex Factors[MESH]
  • |Sjogren's Syndrome/drug therapy/epidemiology[MESH]
  • |Spain/epidemiology[MESH]
  • |Spondylarthropathies/drug therapy/epidemiology[MESH]


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