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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 mBio 2020 ; 11 (4): ä Nephropedia Template TP
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Rethinking Gain-of-Function Experiments in the Context of the COVID-19 Pandemic #MMPMID32769091
Imperiale MJ; Casadevall A
mBio 2020[Aug]; 11 (4): ä PMID32769091show ga
Proponents of the use of gain-of-function (GOF) experiments with pathogens with pandemic potential (PPP) have argued that such experiments are necessary because they reveal important facets of pathogenesis and can be performed safely. Opponents of GOF experiments with PPP have argued that the risks outweigh the knowledge gained. The COVID-19 pandemic demonstrates the vulnerability of human societies to a new PPP, while also validating some arguments of both camps, questioning others, and suggesting the need to rethink how we approach this class of experiments.