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10.1016/j.jcv.2020.104574

http://scihub22266oqcxt.onion/10.1016/j.jcv.2020.104574
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32769026!7395815!32769026
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suck abstract from ncbi


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pmid32769026      J+Clin+Virol 2020 ; 130 (ä): 104574
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  • Nosocomial outbreak of SARS-CoV-2 infection in a haematological unit - High mortality rate in infected patients with haematologic malignancies #MMPMID32769026
  • Biernat MM; Zinczuk A; Biernat P; Bogucka-Fedorczuk A; Kwiatkowski J; Kalicinska E; Marciniak D; Simon K; Wrobel T
  • J Clin Virol 2020[Sep]; 130 (ä): 104574 PMID32769026show ga
  • BACKGROUND: Here we report nosocomial outbreak of COVID-19 among patients in a haematological unit. To our knowledge this is the first report from Central Europe comparing morbidity and mortality in infected and non-infected patients after exposure to SARS-CoV-2. METHODS: The outbreak involved 39 individuals: 19 patients and 20 health care workers. The SARS-CoV-2 test by nasopharyngeal swabs was performed by real-time RT-PCR. Exposed patients were divided into two groups: quarantine patients with and without COVID-19. All patients were prospectively examined at the following time points: 0, 7 days, 14 days, 21 days and 28 days after confirmation or exclusion of SARS-CoV-2. RESULTS: Infection was confirmed in a total of 5/20 health care workers and 10/19 patients. Among the patients positive for SARS-CoV-2 infection, the mortality rate was 36.8 %. The probability of death in patients infected with SARS-CoV-2 increased 8-fold (p = 0.03). Bacterial, fungal, and viral co-infection significantly decreased survival in these patients (p < 0.05). Additionally, the probability of death was much higher in patients older than 40 years of age (p = 0.032). CONCLUSION: This study showed significantly higher mortality rate in COVID-19 patients with haematologic diseases compared to the non-infected patient group. Haematologic patients with COVID-19 have 50 % less chance of survival.
  • |Adult[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coinfection/microbiology/mortality/virology[MESH]
  • |Coronavirus Infections/*mortality[MESH]
  • |Cross Infection/*mortality/virology[MESH]
  • |Europe/epidemiology[MESH]
  • |Female[MESH]
  • |Health Personnel/statistics & numerical data[MESH]
  • |Hematologic Neoplasms/*complications[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*mortality[MESH]
  • |Prospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Time Factors[MESH]


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