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10.1016/j.meegid.2020.104493 http://scihub22266oqcxt.onion/10.1016/j.meegid.2020.104493 32768565!7405773!32768565     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Infect+Genet+Evol 2020 ; 84 (ä): 104493 Nephropedia Template TP {{tp|p=32768565|t=2020. COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans |pdf=|usr=}}{{32768565}} gab.com Text COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans JO: Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=32768565 #FOAvip The emergence of COVID-19 has triggered many works aiming at identifying the animal intermediate potentially involved in the transmission of SARS-CoV-2 to humans. The presence of SARS-CoV-2-related viruses in Malayan pangolins, in silico analysis of the ACE2 receptor polymorphism and sequence similarities between the Receptor Binding Domain (RBD) of the spike proteins of pangolin and human Sarbecoviruses led to the proposal of pangolin as intermediary. However, the binding affinity of the pangolin ACE2 receptor for SARS-CoV-2 RBD was later on reported to be low. Here, we provide evidence that the pangolin is not the intermediate animal at the origin of the human pandemic. Moreover, data available do not fit with the spillover model currently proposed for zoonotic emergence which is thus unlikely to account for this outbreak. We propose a different model to explain how SARS-CoV-2 related coronaviruses could have circulated in different species, including humans, before the emergence of COVID-19. Twit Text FOAVip COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans ????Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=32768565 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32768565 #FOAvip English Wikipedia <ref>{{Cite pmid|32768565}}</ref> COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans #MMPMID32768565 Frutos R; Serra-Cobo J; Chen T; Devaux CA Infect Genet Evol 2020[Oct]; 84 (ä): 104493 PMID32768565show ga The emergence of COVID-19 has triggered many works aiming at identifying the animal intermediate potentially involved in the transmission of SARS-CoV-2 to humans. The presence of SARS-CoV-2-related viruses in Malayan pangolins, in silico analysis of the ACE2 receptor polymorphism and sequence similarities between the Receptor Binding Domain (RBD) of the spike proteins of pangolin and human Sarbecoviruses led to the proposal of pangolin as intermediary. However, the binding affinity of the pangolin ACE2 receptor for SARS-CoV-2 RBD was later on reported to be low. Here, we provide evidence that the pangolin is not the intermediate animal at the origin of the human pandemic. Moreover, data available do not fit with the spillover model currently proposed for zoonotic emergence which is thus unlikely to account for this outbreak. We propose a different model to explain how SARS-CoV-2 related coronaviruses could have circulated in different species, including humans, before the emergence of COVID-19. |*Pandemics[MESH] |Amino Acid Sequence[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus/classification/*genetics/metabolism[MESH] |COVID-19[MESH] |Chiroptera/*virology[MESH] |Coronavirus Infections/*epidemiology/transmission/virology[MESH] |Eutheria/*virology[MESH] |Gene Expression[MESH] |Host-Pathogen Interactions/genetics[MESH] |Humans[MESH] |Peptidyl-Dipeptidase A/*genetics/metabolism[MESH] |Phylogeny[MESH] |Pneumonia, Viral/*epidemiology/transmission/virology[MESH] |Protein Binding[MESH] |SARS-CoV-2[MESH] |Sequence Alignment[MESH] |Sequence Homology, Amino Acid[MESH] |Spike Glycoprotein, Coronavirus/*genetics/metabolism[MESH]COVID-19: Time to exonerate the pangolin from the transmission of SARS(epmc).pdf DeepDyve Pubget Overpricing