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Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Med+Virol 2021 ; 93 (3): 1403-1408 Nephropedia Template TP
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Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells #MMPMID32767684
Ko M; Jeon S; Ryu WS; Kim S
J Med Virol 2021[Mar]; 93 (3): 1403-1408 PMID32767684show ga
Drug repositioning represents an effective way to control the current COVID-19 pandemic. Previously, we identified 24 FDA-approved drugs which exhibited substantial antiviral effect against severe acute respiratory syndrome coronavirus 2 in Vero cells. Since antiviral efficacy could be altered in different cell lines, we developed an antiviral screening assay with human lung cells, which is more appropriate than Vero cell. The comparative analysis of antiviral activities revealed that nafamostat is the most potent drug in human lung cells (IC(50) = 0.0022 microM).