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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Eur+Rev+Med+Pharmacol+Sci 2020 ; 24 (15): 8187-8193 Nephropedia Template TP
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Inhibitory effects of Vitamin D on inflammation and IL-6 release A further support for COVID-19 management? #MMPMID32767348
Orru B; Szekeres-Bartho J; Bizzarri M; Spiga AM; Unfer V
Eur Rev Med Pharmacol Sci 2020[Aug]; 24 (15): 8187-8193 PMID32767348show ga
The ongoing worldwide pandemic of Coronavirus disease 2019 (COVID-19), raised the urgency to address knowledge gaps and to establish evidence for improving management and control of this viral infection. Throughout a keen analysis of the World Health Organization (WHO) most updated data, a gender-specific difference in the occurrence of infection was determined, which seems to correlate with patient's vitamin D status. Therefore, our purpose is to provide insights into the nutritional importance of vitamin D for its immunomodulatory effect, in order to help counteracting the COVID-19 pandemic. Novel interesting findings suggest that vitamin D, by inducing progesterone-induced blocking factor (PIBF), might regulate the immune response and also modulate cytokine IL-6, which appears to be increased in COVID-19 infections. Therefore, in addition to the standard recommendations to prevent the infection, supplementation of vitamin D might be considered an approach to help counteracting this global epidemic.