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10.1007/s11596-020-2225-x http://scihub22266oqcxt.onion/10.1007/s11596-020-2225-x 32767259!7412778!32767259     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Med+Sci 2020 ; 40 (4): 618-624 Nephropedia Template TP {{tp|p=32767259|t=2020. Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients |pdf=|usr=}}{{32767259}} gab.com Text Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients JO: Curr Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=32767259 #FOAvip The COVID-19 pandemic caused by SARS-CoV2 is characterized by a remarkable variation in clinical severity ranging from a mild illness to a fatal multi-organ disease. Understanding the dysregulated human immune responses in the fatal subjects is critical for management of COVID-19 patients and the pandemic. In this study, we examined the immune cell compositions in the lung tissues and hilar lymph nodes using immunohistochemistry on 6 deceased COVID-19 patients and 4 focal organizing pneumonia (FOP) patients who underwent lung surgery and served as controls. We found a dominant presence of macrophages and a general deficiency of T cells and B cells in the lung tissues from deceased COVID-19 patients. In contrast to the FOP patients, Tfh cells and germinal center formation were largely absent in the draining hilar lymph nodes in the deceased COVID-19 patients. This was correlated with reduced IgM and IgG levels compared to convalescent COVID-19 patients. In summary, our data highlight a defect of germinal center structure in deceased COVID-19 patients leading to an impaired humoral immunity. Understanding the mechanisms of this deficiency will be one of the key points for the management of this epidemic. Twit Text FOAVip Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients ????Curr Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=32767259 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32767259 #FOAvip English Wikipedia <ref>{{Cite pmid|32767259}}</ref> Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients #MMPMID32767259 Duan YQ; Xia MH; Ren L; Zhang YF; Ao QL; Xu SP; Kuang D; Liu Q; Yan B; Zhou YW; Chu Q; Liu L; Yang XP; Wang GP Curr Med Sci 2020[Aug]; 40 (4): 618-624 PMID32767259show ga The COVID-19 pandemic caused by SARS-CoV2 is characterized by a remarkable variation in clinical severity ranging from a mild illness to a fatal multi-organ disease. Understanding the dysregulated human immune responses in the fatal subjects is critical for management of COVID-19 patients and the pandemic. In this study, we examined the immune cell compositions in the lung tissues and hilar lymph nodes using immunohistochemistry on 6 deceased COVID-19 patients and 4 focal organizing pneumonia (FOP) patients who underwent lung surgery and served as controls. We found a dominant presence of macrophages and a general deficiency of T cells and B cells in the lung tissues from deceased COVID-19 patients. In contrast to the FOP patients, Tfh cells and germinal center formation were largely absent in the draining hilar lymph nodes in the deceased COVID-19 patients. This was correlated with reduced IgM and IgG levels compared to convalescent COVID-19 patients. In summary, our data highlight a defect of germinal center structure in deceased COVID-19 patients leading to an impaired humoral immunity. Understanding the mechanisms of this deficiency will be one of the key points for the management of this epidemic. |*Betacoronavirus[MESH] |Adaptive Immunity[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19[MESH] |Case-Control Studies[MESH] |China/epidemiology[MESH] |Coronavirus Infections/*immunology/mortality/pathology[MESH] |Fatal Outcome[MESH] |Female[MESH] |Germinal Center/*immunology/pathology[MESH] |Humans[MESH] |Lymphopenia/immunology/mortality/pathology[MESH] |Macrophages/immunology/pathology[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/mortality/pathology[MESH] |SARS-CoV-2[MESH]Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patie(epmc).pdf DeepDyve Pubget Overpricing