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10.1093/jalm/jfaa139 http://scihub22266oqcxt.onion/10.1093/jalm/jfaa139 32766840!7454554!32766840     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Appl+Lab+Med 2020 ; 5 (6): 1324-1336 Nephropedia Template TP {{tp|p=32766840|t=2020. Multi-Platform Comparison of SARS-CoV-2 Serology Assays for the Detection of COVID-19 |pdf=|usr=}}{{32766840}} gab.com Text Multi-Platform Comparison of SARS-CoV-2 Serology Assays for the Detection of COVID-19 JO: J Appl Lab Med http://www.kidney.de/pget.php?&tw=1&pmid=32766840 #FOAvip BACKGROUND: COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel beta-coronavirus that is responsible for the 2019 coronavirus pandemic. Acute infections should be diagnosed by polymerase chain reaction (PCR) based tests, but serology tests can demonstrate previous exposure to the virus. METHODS: We compared the performance of the Diazyme, Roche, and Abbott SARS-CoV-2 serology assays using 179 negative participants to determine negative percentage agreement (NPA) and in 60 SARS-CoV-2 PCR-confirmed positive patients to determine positive percentage agreement (PPA) at 3 different time frames following a positive SARS-CoV-2 PCR result. RESULTS: At >/=15 days, the PPA (95% CI) was 100 (86.3-100)% for the Diazyme IgM/IgG panel, 96.0 (79.7-99.9)% for the Roche total Ig assay, and 100 (86.3-100)% for the Abbott IgG assay. The NPA (95% CI) was 98.3 (95.2-99.7)% for the Diazyme IgM/IgG panel, 99.4 (96.9-100)% for the Roche total Ig assay, and 98.9 (96.0-99.9)% for the Abbott IgG assay. When the Roche total Ig assay was combined with either the Diazyme IgM/IgG panel or the Abbott IgG assay, the positive predictive value was 100% while the negative predictive value remained greater than 99%. CONCLUSIONS: Our data demonstrates that the Diazyme, Roche, and Abbott SARS-CoV-2 serology assays have similar clinical performances. We demonstrated a low false-positive rate across all 3 platforms and observed that false positives observed on the Roche platform are unique compared to those observed on the Diazyme or Abbott assays. Using multiple platforms in tandem increases the PPVs, which is important when screening populations with low disease prevalence. Twit Text FOAVip Multi-Platform Comparison of SARS-CoV-2 Serology Assays for the Detection of COVID-19 ????J Appl Lab Med http://www.kidney.de/pget.php?&tw=1&pmid=32766840 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32766840 #FOAvip English Wikipedia <ref>{{Cite pmid|32766840}}</ref> Multi-Platform Comparison of SARS-CoV-2 Serology Assays for the Detection of COVID-19 #MMPMID32766840 Suhandynata RT; Hoffman MA; Kelner MJ; McLawhon RW; Reed SL; Fitzgerald RL J Appl Lab Med 2020[Nov]; 5 (6): 1324-1336 PMID32766840show ga BACKGROUND: COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel beta-coronavirus that is responsible for the 2019 coronavirus pandemic. Acute infections should be diagnosed by polymerase chain reaction (PCR) based tests, but serology tests can demonstrate previous exposure to the virus. METHODS: We compared the performance of the Diazyme, Roche, and Abbott SARS-CoV-2 serology assays using 179 negative participants to determine negative percentage agreement (NPA) and in 60 SARS-CoV-2 PCR-confirmed positive patients to determine positive percentage agreement (PPA) at 3 different time frames following a positive SARS-CoV-2 PCR result. RESULTS: At >/=15 days, the PPA (95% CI) was 100 (86.3-100)% for the Diazyme IgM/IgG panel, 96.0 (79.7-99.9)% for the Roche total Ig assay, and 100 (86.3-100)% for the Abbott IgG assay. The NPA (95% CI) was 98.3 (95.2-99.7)% for the Diazyme IgM/IgG panel, 99.4 (96.9-100)% for the Roche total Ig assay, and 98.9 (96.0-99.9)% for the Abbott IgG assay. When the Roche total Ig assay was combined with either the Diazyme IgM/IgG panel or the Abbott IgG assay, the positive predictive value was 100% while the negative predictive value remained greater than 99%. CONCLUSIONS: Our data demonstrates that the Diazyme, Roche, and Abbott SARS-CoV-2 serology assays have similar clinical performances. We demonstrated a low false-positive rate across all 3 platforms and observed that false positives observed on the Roche platform are unique compared to those observed on the Diazyme or Abbott assays. Using multiple platforms in tandem increases the PPVs, which is important when screening populations with low disease prevalence. |Antibodies, Viral/blood/immunology/*isolation & purification[MESH] |Betacoronavirus/immunology/*isolation & purification[MESH] |COVID-19[MESH] |COVID-19 Testing[MESH] |Clinical Laboratory Techniques/*instrumentation/statistics & numerical data[MESH] |Coronavirus Infections/blood/*diagnosis/immunology/virology[MESH] |False Negative Reactions[MESH] |False Positive Reactions[MESH] |Humans[MESH] |Immunoglobulin G/blood/immunology/isolation & purification[MESH] |Longitudinal Studies[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*diagnosis/immunology/virology[MESH] |Predictive Value of Tests[MESH] |Reagent Kits, Diagnostic/statistics & numerical data[MESH] |SARS-CoV-2[MESH] |Serologic Tests/*instrumentation/statistics & numerical data[MESH]Multi-Platform Comparison of SARS-CoV-2 Serology Assays for the Detect(epmc).pdf DeepDyve Pubget Overpricing