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10.1093/jac/dkaa326

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32766706!7454563!32766706
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suck abstract from ncbi


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pmid32766706      J+Antimicrob+Chemother 2020 ; 75 (11): 3386-3390
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  • Antibiotic use in patients with COVID-19: a snapshot Infectious Diseases International Research Initiative (ID-IRI) survey #MMPMID32766706
  • Beovic B; Dousak M; Ferreira-Coimbra J; Nadrah K; Rubulotta F; Belliato M; Berger-Estilita J; Ayoade F; Rello J; Erdem H
  • J Antimicrob Chemother 2020[Nov]; 75 (11): 3386-3390 PMID32766706show ga
  • BACKGROUND: Antibiotics may be indicated in patients with COVID-19 due to suspected or confirmed bacterial superinfection. OBJECTIVES: To investigate antibiotic prescribing practices in patients with COVID-19. METHODS: We performed an international web-based survey and investigated the pattern of antibiotic use as reported by physicians involved in treatment of COVID-19. SPSS Statistics version 25 was used for data analysis. RESULTS: The survey was completed by 166 participants from 23 countries and 82 different hospitals. Local guidelines for antibiotic use in COVID-19 patients were reported by 61.8% (n = 102) of participants and for 82.9% (n = 136) they did not differ from local community-acquired pneumonia guidelines. Clinical presentation was recognized as the most important reason for the start of antibiotics (mean score = 4.07 and SD = 1.095 on grading scale from 1 to 5). When antibiotics were started, most respondents rated as the highest the need for coverage of atypical pathogens (mean score = 2.8 and SD = 0.99), followed by Staphylococcus aureus (mean score = 2.67 and SD = 1.05 on bi-modal scale, with values 1 and 2 for disagreement and values 3 and 4 for agreement). In the patients on the ward, 29.1% of respondents chose not to prescribe any antibiotic. Combination of beta-lactams and macrolides or fluoroquinolones was reported by 52.4% (n = 87) of respondents. In patients in the ICU, piperacillin/tazobactam was the most commonly prescribed antibiotic. The mean reported duration of antibiotic treatment was 7.12 (SD = 2.44) days. CONCLUSIONS: The study revealed widespread broad-spectrum antibiotic use in patients with COVID-19. Implementation of antimicrobial stewardship principles is warranted to mitigate the negative consequences of antibiotic therapy.
  • |*Betacoronavirus[MESH]
  • |*Drug Prescriptions/statistics & numerical data[MESH]
  • |*Internationality[MESH]
  • |*Surveys and Questionnaires[MESH]
  • |Anti-Bacterial Agents/*administration & dosage[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy/epidemiology[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/epidemiology[MESH]


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