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10.1101/2020.07.29.227462

http://scihub22266oqcxt.onion/10.1101/2020.07.29.227462
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32766577!7402034!32766577
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suck abstract from ncbi


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pmid32766577      bioRxiv 2020 ; ä (ä): ä
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  • SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors #MMPMID32766577
  • Gao C; Zeng J; Jia N; Stavenhagen K; Matsumoto Y; Zhang H; Li J; Hume AJ; Muhlberger E; van Die I; Kwan J; Tantisira K; Emili A; Cummings RD
  • bioRxiv 2020[Jul]; ä (ä): ä PMID32766577show ga
  • The spike (S) glycoprotein in the envelope of SARS-CoV-2 is densely glycosylated but the functions of its glycosylation are unknown. Here we demonstrate that S is recognized in a glycan-dependent manner by multiple innate immune receptors including the mannose receptor MR/CD206, DC-SIGN/CD209, L-SIGN/CD209L, and MGL/CLEC10A/CD301. Single-cell RNA sequencing analyses indicate that such receptors are highly expressed in innate immune cells in tissues susceptible to SARS-CoV-2 infection. Binding of the above receptors to S is characterized by affinities in the picomolar range and consistent with S glycosylation analysis demonstrating a variety of N- and O-glycans as receptor ligands. These results indicate multiple routes for SARS-CoV-2 to interact with human cells and suggest alternative strategies for therapeutic intervention.
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