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10.14336/AD.2020.0619 http://scihub22266oqcxt.onion/10.14336/AD.2020.0619 32765940!7390514!32765940     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+Dis 2020 ; 11 (4): 742-745 Nephropedia Template TP {{tp|p=32765940|t=2020. Decreased Naive T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities |pdf=|usr=}}{{32765940}} gab.com Text Decreased Naive T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities JO: Aging Dis http://www.kidney.de/pget.php?&tw=1&pmid=32765940 #FOAvip Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naive T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naive T-cell populations after bone marrow transplantation is delayed and associated with an increased risk of chronic graft vs. host disease. Severe COVID-19 and SARS infections are notable for severe T-cell depletion. In COVID-19, there is unique suppression of interferon signaling by infected respiratory tract cells with intact cytokine signaling. A decreased naive T-cell response likely contributes to an excessive inflammatory response and increases the odds of a cytokine storm. Treatments that improve naive T-cell production may prove to be vital COVID-19 therapies, especially for these high-risk groups. Twit Text FOAVip Decreased Naive T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities ????Aging Dis http://www.kidney.de/pget.php?&tw=1&pmid=32765940 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32765940 #FOAvip English Wikipedia <ref>{{Cite pmid|32765940}}</ref> Decreased Naive T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities #MMPMID32765940 Schwartz MD; Emerson SG; Punt J; Goff WD Aging Dis 2020[Jul]; 11 (4): 742-745 PMID32765940show ga Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naive T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naive T-cell populations after bone marrow transplantation is delayed and associated with an increased risk of chronic graft vs. host disease. Severe COVID-19 and SARS infections are notable for severe T-cell depletion. In COVID-19, there is unique suppression of interferon signaling by infected respiratory tract cells with intact cytokine signaling. A decreased naive T-cell response likely contributes to an excessive inflammatory response and increases the odds of a cytokine storm. Treatments that improve naive T-cell production may prove to be vital COVID-19 therapies, especially for these high-risk groups. äDecreased Naive T-cell Production Leading to Cytokine Storm as Cause o(epmc).pdf DeepDyve Pubget Overpricing