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10.1038/s41467-020-17796-z http://scihub22266oqcxt.onion/10.1038/s41467-020-17796-z 32764693!7413383!32764693     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 3910 Nephropedia Template TP {{tp|p=32764693|t=2020. Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells |pdf=|usr=}}{{32764693}} gab.com Text Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32764693 #FOAvip SARS-CoV-2, a beta-coronavirus, has rapidly spread across the world, highlighting its high transmissibility, but the underlying morphogenesis and pathogenesis remain poorly understood. Here, we characterize the replication dynamics, cell tropism and morphogenesis of SARS-CoV-2 in organotypic human airway epithelial (HAE) cultures. SARS-CoV-2 replicates efficiently and infects both ciliated and secretory cells in HAE cultures. In comparison, HCoV-NL63 replicates to lower titers and is only detected in ciliated cells. SARS-CoV-2 shows a similar morphogenetic process as other coronaviruses but causes plaque-like cytopathic effects in HAE cultures. Cell fusion, apoptosis, destruction of epithelium integrity, cilium shrinking and beaded changes are observed in the plaque regions. Taken together, our results provide important insights into SARS-CoV-2 cell tropism, replication and morphogenesis. Twit Text FOAVip Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32764693 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32764693 #FOAvip English Wikipedia <ref>{{Cite pmid|32764693}}</ref> Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells #MMPMID32764693 Zhu N; Wang W; Liu Z; Liang C; Wang W; Ye F; Huang B; Zhao L; Wang H; Zhou W; Deng Y; Mao L; Su C; Qiang G; Jiang T; Zhao J; Wu G; Song J; Tan W Nat Commun 2020[Aug]; 11 (1): 3910 PMID32764693show ga SARS-CoV-2, a beta-coronavirus, has rapidly spread across the world, highlighting its high transmissibility, but the underlying morphogenesis and pathogenesis remain poorly understood. Here, we characterize the replication dynamics, cell tropism and morphogenesis of SARS-CoV-2 in organotypic human airway epithelial (HAE) cultures. SARS-CoV-2 replicates efficiently and infects both ciliated and secretory cells in HAE cultures. In comparison, HCoV-NL63 replicates to lower titers and is only detected in ciliated cells. SARS-CoV-2 shows a similar morphogenetic process as other coronaviruses but causes plaque-like cytopathic effects in HAE cultures. Cell fusion, apoptosis, destruction of epithelium integrity, cilium shrinking and beaded changes are observed in the plaque regions. Taken together, our results provide important insights into SARS-CoV-2 cell tropism, replication and morphogenesis. |Betacoronavirus/pathogenicity/*physiology[MESH] |COVID-19[MESH] |Cell Line[MESH] |Cells, Cultured[MESH] |Coronavirus Infections/*virology[MESH] |Cytopathogenic Effect, Viral[MESH] |Epithelial Cells/pathology/*virology[MESH] |Humans[MESH] |Morphogenesis/*physiology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*virology[MESH] |Respiratory System/pathology/*virology[MESH] |SARS-CoV-2[MESH] |Tropism[MESH]Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human a(epmc).pdf DeepDyve Pubget Overpricing