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10.1038/s41467-020-17834-w http://scihub22266oqcxt.onion/10.1038/s41467-020-17834-w 32764665!7413381!32764665     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 3924 Nephropedia Template TP {{tp|p=32764665|t=2020. Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm |pdf=|usr=}}{{32764665}} gab.com Text Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32764665 #FOAvip Several studies show that the immunosuppressive drugs targeting the interleukin-6 (IL-6) receptor, including tocilizumab, ameliorate lethal inflammatory responses in COVID-19 patients infected with SARS-CoV-2. Here, by employing single-cell analysis of the immune cell composition of two severe-stage COVID-19 patients prior to and following tocilizumab-induced remission, we identify a monocyte subpopulation that contributes to the inflammatory cytokine storms. Furthermore, although tocilizumab treatment attenuates the inflammation, immune cells, including plasma B cells and CD8(+) T cells, still exhibit robust humoral and cellular antiviral immune responses. Thus, in addition to providing a high-dimensional dataset on the immune cell distribution at multiple stages of the COVID-19, our work also provides insights into the therapeutic effects of tocilizumab, and identifies potential target cell populations for treating COVID-19-related cytokine storms. Twit Text FOAVip Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=32764665 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32764665 #FOAvip English Wikipedia <ref>{{Cite pmid|32764665}}</ref> Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm #MMPMID32764665 Guo C; Li B; Ma H; Wang X; Cai P; Yu Q; Zhu L; Jin L; Jiang C; Fang J; Liu Q; Zong D; Zhang W; Lu Y; Li K; Gao X; Fu B; Liu L; Ma X; Weng J; Wei H; Jin T; Lin J; Qu K Nat Commun 2020[Aug]; 11 (1): 3924 PMID32764665show ga Several studies show that the immunosuppressive drugs targeting the interleukin-6 (IL-6) receptor, including tocilizumab, ameliorate lethal inflammatory responses in COVID-19 patients infected with SARS-CoV-2. Here, by employing single-cell analysis of the immune cell composition of two severe-stage COVID-19 patients prior to and following tocilizumab-induced remission, we identify a monocyte subpopulation that contributes to the inflammatory cytokine storms. Furthermore, although tocilizumab treatment attenuates the inflammation, immune cells, including plasma B cells and CD8(+) T cells, still exhibit robust humoral and cellular antiviral immune responses. Thus, in addition to providing a high-dimensional dataset on the immune cell distribution at multiple stages of the COVID-19, our work also provides insights into the therapeutic effects of tocilizumab, and identifies potential target cell populations for treating COVID-19-related cytokine storms. |Antibodies, Monoclonal, Humanized/administration & dosage/*adverse effects[MESH] |B-Lymphocytes/drug effects/immunology[MESH] |Betacoronavirus/*immunology[MESH] |CD8-Positive T-Lymphocytes/drug effects/immunology[MESH] |COVID-19[MESH] |Computational Biology[MESH] |Coronavirus Infections/blood/drug therapy/*immunology/virology[MESH] |Cytokines/blood/*immunology[MESH] |Humans[MESH] |Inflammation/drug therapy[MESH] |Macrophages/drug effects/immunology[MESH] |Monocytes/*immunology[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/drug therapy/*immunology/virology[MESH] |Receptors, Interleukin-6/immunology[MESH] |SARS-CoV-2[MESH]Single-cell analysis of two severe COVID-19 patients reveals a monocy(epmc).pdf DeepDyve Pubget Overpricing