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10.14309/ctg.0000000000000215 http://scihub22266oqcxt.onion/10.14309/ctg.0000000000000215 32764201!7386395!32764201     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Transl+Gastroenterol 2020 ; 11 (7): e00215 Nephropedia Template TP {{tp|p=32764201|t=2020. Marked Elevation of Lipase in COVID-19 Disease: A Cohort Study |pdf=|usr=}}{{32764201}} gab.com Text Marked Elevation of Lipase in COVID-19 Disease: A Cohort Study JO: Clin Transl Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=32764201 #FOAvip INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the pandemic of coronavirus disease 2019 (COVID-19) is a global health crisis. Possible pancreatic involvement has recently been observed in these patients; however, its significance is unclear. The aim of this study was to evaluate the association of significantly elevated lipase with disease outcomes. METHODS: Data about demographics, symptoms, laboratory values, and clinical outcomes were collected for 1,003 consecutive patients testing positive for COVID-19. Elevated lipase was defined as greater than 3 times the upper limit of normal (>3 x ULN). Baseline characteristics among patients with or without elevated lipase were compared using Fisher exact test or Student t-test for categorical or numerical variables, respectively. Logistic regression was used to evaluate the association of lipase levels with primary clinical outcomes (intensive care unit admission and intubation) adjusted for age, sex, body mass index, history of diabetes, and hypertension. RESULTS: Of 1,003 patients with COVID-19, 83 had available lipase levels and were all admitted to the hospital. Of 83, 14 (16.8%) had elevated lipase (>3 x ULN), which was associated with higher rates of leukocytosis (P < 0.001) and abnormal liver enzymes (P < 0.01). Compared with lower lipase levels (<3 x ULN), patients with elevated lipase had higher rates of ICU admission (92.9% vs 32.8%; P < 0.001) and intubation (78.6% vs 23.5%; P 0.002). In a multivariable-adjusted model, higher lipase levels were significantly associated with admission to the ICU and rate of intubation. DISCUSSION: Lipase elevation is seen in COVID-19 and is associated with worse disease outcomes. Twit Text FOAVip Marked Elevation of Lipase in COVID-19 Disease: A Cohort Study ????Clin Transl Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=32764201 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32764201 #FOAvip English Wikipedia <ref>{{Cite pmid|32764201}}</ref> Marked Elevation of Lipase in COVID-19 Disease: A Cohort Study #MMPMID32764201 Barlass U; Wiliams B; Dhana K; Adnan D; Khan SR; Mahdavinia M; Bishehsari F Clin Transl Gastroenterol 2020[Jul]; 11 (7): e00215 PMID32764201show ga INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the pandemic of coronavirus disease 2019 (COVID-19) is a global health crisis. Possible pancreatic involvement has recently been observed in these patients; however, its significance is unclear. The aim of this study was to evaluate the association of significantly elevated lipase with disease outcomes. METHODS: Data about demographics, symptoms, laboratory values, and clinical outcomes were collected for 1,003 consecutive patients testing positive for COVID-19. Elevated lipase was defined as greater than 3 times the upper limit of normal (>3 x ULN). Baseline characteristics among patients with or without elevated lipase were compared using Fisher exact test or Student t-test for categorical or numerical variables, respectively. Logistic regression was used to evaluate the association of lipase levels with primary clinical outcomes (intensive care unit admission and intubation) adjusted for age, sex, body mass index, history of diabetes, and hypertension. RESULTS: Of 1,003 patients with COVID-19, 83 had available lipase levels and were all admitted to the hospital. Of 83, 14 (16.8%) had elevated lipase (>3 x ULN), which was associated with higher rates of leukocytosis (P < 0.001) and abnormal liver enzymes (P < 0.01). Compared with lower lipase levels (<3 x ULN), patients with elevated lipase had higher rates of ICU admission (92.9% vs 32.8%; P < 0.001) and intubation (78.6% vs 23.5%; P 0.002). In a multivariable-adjusted model, higher lipase levels were significantly associated with admission to the ICU and rate of intubation. DISCUSSION: Lipase elevation is seen in COVID-19 and is associated with worse disease outcomes. |*Betacoronavirus/isolation & purification/physiology[MESH] |*Coronavirus Infections/blood/diagnosis/epidemiology/physiopathology[MESH] |*Obesity/diagnosis/epidemiology[MESH] |*Pancreas/metabolism/physiopathology/virology[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/blood/diagnosis/epidemiology/physiopathology[MESH] |Aged[MESH] |Body Mass Index[MESH] |COVID-19[MESH] |Cohort Studies[MESH] |Female[MESH] |Humans[MESH] |Lipase/*blood[MESH] |Male[MESH] |Middle Aged[MESH] |Risk Factors[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH] |Sex Factors[MESH] |Symptom Assessment/methods/statistics & numerical data[MESH]Marked Elevation of Lipase in COVID-19 Disease: A Cohort Study (epmc).pdf DeepDyve Pubget Overpricing