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10.1126/science.abd3629 http://scihub22266oqcxt.onion/10.1126/science.abd3629 32763915!7665310!32763915     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2020 ; 369 (6509): 1395-1398 Nephropedia Template TP {{tp|p=32763915|t=2020. A molecular pore spans the double membrane of the coronavirus replication organelle |pdf=|usr=}}{{32763915}} gab.com Text A molecular pore spans the double membrane of the coronavirus replication organelle JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=32763915 #FOAvip Coronavirus genome replication is associated with virus-induced cytosolic double-membrane vesicles, which may provide a tailored microenvironment for viral RNA synthesis in the infected cell. However, it is unclear how newly synthesized genomes and messenger RNAs can travel from these sealed replication compartments to the cytosol to ensure their translation and the assembly of progeny virions. In this study, we used cellular cryo-electron microscopy to visualize a molecular pore complex that spans both membranes of the double-membrane vesicle and would allow export of RNA to the cytosol. A hexameric assembly of a large viral transmembrane protein was found to form the core of the crown-shaped complex. This coronavirus-specific structure likely plays a key role in coronavirus replication and thus constitutes a potential drug target. Twit Text FOAVip A molecular pore spans the double membrane of the coronavirus replication organelle ????Science http://www.kidney.de/pget.php?&tw=1&pmid=32763915 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32763915 #FOAvip English Wikipedia <ref>{{Cite pmid|32763915}}</ref> A molecular pore spans the double membrane of the coronavirus replication organelle #MMPMID32763915 Wolff G; Limpens RWAL; Zevenhoven-Dobbe JC; Laugks U; Zheng S; de Jong AWM; Koning RI; Agard DA; Grunewald K; Koster AJ; Snijder EJ; Barcena M Science 2020[Sep]; 369 (6509): 1395-1398 PMID32763915show ga Coronavirus genome replication is associated with virus-induced cytosolic double-membrane vesicles, which may provide a tailored microenvironment for viral RNA synthesis in the infected cell. However, it is unclear how newly synthesized genomes and messenger RNAs can travel from these sealed replication compartments to the cytosol to ensure their translation and the assembly of progeny virions. In this study, we used cellular cryo-electron microscopy to visualize a molecular pore complex that spans both membranes of the double-membrane vesicle and would allow export of RNA to the cytosol. A hexameric assembly of a large viral transmembrane protein was found to form the core of the crown-shaped complex. This coronavirus-specific structure likely plays a key role in coronavirus replication and thus constitutes a potential drug target. |*Virus Replication[MESH] |Animals[MESH] |Cryoelectron Microscopy[MESH] |Cytoplasmic Vesicles/*chemistry/ultrastructure/virology[MESH] |Electron Microscope Tomography[MESH] |Intracellular Membranes/*chemistry/ultrastructure/virology[MESH] |Mice[MESH] |Murine hepatitis virus/*physiology[MESH] |RNA, Viral/*biosynthesis[MESH]A molecular pore spans the double membrane of the coronavirus replicat(epmc).pdf DeepDyve Pubget Overpricing