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10.1016/j.mehy.2020.110153

http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.110153
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32763662!7392877!32763662
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suck abstract from ncbi


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pmid32763662      Med+Hypotheses 2020 ; 143 (ä): 110153
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  • A putative role for the tobacco mosaic virus in smokers resistance to COVID-19 #MMPMID32763662
  • de Bernardis E; Busa L
  • Med Hypotheses 2020[Oct]; 143 (ä): 110153 PMID32763662show ga
  • Reports from various countries suggest that tobacco smoking might protect from SARS-CoV-2 infection, since the prevalence of smoking in COVID-19 hospitalized patients is lower than in the respective general population. Apart from nicotine or other chemicals contained in tobacco smoke, we propose that a single-stranded RNA virus that infects tobacco leaves, tobacco mosaic virus (TMV), might be implicated in this effect. TMV, though non-pathogenic, is found in smokers' airways, and stimulates adaptive and innate immunity, with release of specific antibodies and interferons. The latter may have preventive and/or therapeutic effects against COVID-19. If confirmed by epidemiological and interventional studies, this might lead to the use of TMV as an immunological adjuvant against SARS-CoV-2 infection and COVID-19 disease.
  • |*Models, Immunological[MESH]
  • |*Pandemics[MESH]
  • |*Smokers[MESH]
  • |*Tobacco Smoking/epidemiology[MESH]
  • |Animals[MESH]
  • |Antibodies, Viral/biosynthesis[MESH]
  • |Betacoronavirus/*immunology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/epidemiology/*immunology/virology[MESH]
  • |Disease Resistance[MESH]
  • |Humans[MESH]
  • |Interferons/biosynthesis[MESH]
  • |Mice[MESH]
  • |Pneumonia, Viral/epidemiology/*immunology/virology[MESH]
  • |Respiratory System/immunology/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Tobacco Mosaic Virus/*immunology/isolation & purification[MESH]
  • |Tobacco Products/*virology[MESH]


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