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10.1016/j.mehy.2020.110151 http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.110151 32763661!7392903!32763661     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Hypotheses 2020 ; 143 (ä): 110151 Nephropedia Template TP {{tp|p=32763661|t=2020. Why do children seem to be more protected against COVID-19? A hypothesis |pdf=|usr=}}{{32763661}} gab.com Text Why do children seem to be more protected against COVID-19 A hypothesis JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32763661 #FOAvip Today it remains unclear why children seem to be less likely to get infected by COVID-19 or why they appear to be less symptomatic after infections. All individuals, especially children, are exposed to various viruses including human coronavirus (CoVs) that can generally lead to respiratory infections. We hypothesize that recurrent CoVs exposure may induce an effective antiviral B and T-cell-mediated adaptive immune response, which could also be protective against COVID-19. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviruses, we theorize that past/recurrent contact with CoVs might shield children also against the circulating COVID-19 through a possible neutralizing antibody response previously CoVs-induced. This would open up possible lines of research for the development of live-attenuated virus vaccines from CoVs. Future research is desirable to confirm or disprove such hypothesis. Twit Text FOAVip Why do children seem to be more protected against COVID-19 A hypothesis ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32763661 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32763661 #FOAvip English Wikipedia <ref>{{Cite pmid|32763661}}</ref> Why do children seem to be more protected against COVID-19? A hypothesis #MMPMID32763661 Sposato B; Scalese M Med Hypotheses 2020[Oct]; 143 (ä): 110151 PMID32763661show ga Today it remains unclear why children seem to be less likely to get infected by COVID-19 or why they appear to be less symptomatic after infections. All individuals, especially children, are exposed to various viruses including human coronavirus (CoVs) that can generally lead to respiratory infections. We hypothesize that recurrent CoVs exposure may induce an effective antiviral B and T-cell-mediated adaptive immune response, which could also be protective against COVID-19. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviruses, we theorize that past/recurrent contact with CoVs might shield children also against the circulating COVID-19 through a possible neutralizing antibody response previously CoVs-induced. This would open up possible lines of research for the development of live-attenuated virus vaccines from CoVs. Future research is desirable to confirm or disprove such hypothesis. |*Betacoronavirus/genetics/immunology[MESH] |*Immunologic Memory[MESH] |*Models, Immunological[MESH] |*Pandemics[MESH] |Adult[MESH] |Age Distribution[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |Antigens, Viral/genetics/immunology[MESH] |CD4-Positive T-Lymphocytes/immunology[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Child[MESH] |Coronavirus Infections/*epidemiology/immunology/prevention & control/virology[MESH] |Coronavirus/genetics/immunology[MESH] |Cross Reactions[MESH] |Disease Resistance[MESH] |Epitopes/genetics/immunology[MESH] |Humans[MESH] |Peptidyl-Dipeptidase A/analysis[MESH] |Pneumonia, Viral/*epidemiology/immunology[MESH] |Pulmonary Alveoli/chemistry[MESH] |Receptors, Virus/analysis[MESH] |Respiratory Tract Infections/epidemiology/immunology/virology[MESH] |SARS-CoV-2[MESH] |Sequence Homology, Amino Acid[MESH] |Spike Glycoprotein, Coronavirus/genetics/immunology[MESH] |Vaccines, Attenuated[MESH]Why do children seem to be more protected against COVID-19? A hypothes(epmc).pdf DeepDyve Pubget Overpricing