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10.1016/j.taap.2020.115182 http://scihub22266oqcxt.onion/10.1016/j.taap.2020.115182 32763356!7403870!32763356     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxicol+Appl+Pharmacol 2020 ; 404 (ä): 115182 Nephropedia Template TP {{tp|p=32763356|t=2020. Formation of lamellar body-like structure may be an initiator of didecyldimethylammonium chloride-induced toxic response |pdf=|usr=}}{{32763356}} gab.com Text Formation of lamellar body-like structure may be an initiator of didecyldimethylammonium chloride-induced toxic response JO: Toxicol Appl Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32763356 #FOAvip Due to the pandemic of coronavirus disease 2019, the use of disinfectants is rapidly increasing worldwide. Didecyldimethylammonium chloride (DDAC) is an EPA-registered disinfectant, it was also a component in humidifier disinfectants that had caused idiopathic pulmonary diseases in Korea. In this study, we identified the possible pulmonary toxic response and mechanism using human bronchial epithelial (BEAS-2B) cells and mice. First, cell viability decreased sharply at a 4 mug/mL of concentration. The volume of intracellular organelles and the ROS level reduced, leading to the formation of apoptotic bodies and an increase of the LDH release. Secretion of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and matrix metalloproteinase-1 also significantly increased. More importantly, lamellar body-like structures were formed in both the cells and mice exposed to DDAC, and the expression of both the indicator proteins for lamellar body (ABCA3 and Rab11a) and surfactant proteins (A, B, and D) was clearly enhanced. In addition, chronic fibrotic pulmonary lesions were notably observed in mice instilled twice (weekly) with DDAC (500 mug), ultimately resulting in death. Taken together, we suggest that disruption of pulmonary surfactant homeostasis may contribute to DDAC-induced cell death and subsequent pathophysiology and that the formation of lamellar body-like structures may play a role as the trigger. In addition, we propose that the cause of sudden death of mice exposed to DDAC should be clearly elucidated for the safe application of DDAC. Twit Text FOAVip Formation of lamellar body-like structure may be an initiator of didecyldimethylammonium chloride-induced toxic response ????Toxicol Appl Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32763356 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32763356 #FOAvip English Wikipedia <ref>{{Cite pmid|32763356}}</ref> Formation of lamellar body-like structure may be an initiator of didecyldimethylammonium chloride-induced toxic response #MMPMID32763356 Park EJ; Seong E; Kang MS; Lee GH; Kim DW; Han JS; Lim HJ; Lee SH; Han HY Toxicol Appl Pharmacol 2020[Oct]; 404 (ä): 115182 PMID32763356show ga Due to the pandemic of coronavirus disease 2019, the use of disinfectants is rapidly increasing worldwide. Didecyldimethylammonium chloride (DDAC) is an EPA-registered disinfectant, it was also a component in humidifier disinfectants that had caused idiopathic pulmonary diseases in Korea. In this study, we identified the possible pulmonary toxic response and mechanism using human bronchial epithelial (BEAS-2B) cells and mice. First, cell viability decreased sharply at a 4 mug/mL of concentration. The volume of intracellular organelles and the ROS level reduced, leading to the formation of apoptotic bodies and an increase of the LDH release. Secretion of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and matrix metalloproteinase-1 also significantly increased. More importantly, lamellar body-like structures were formed in both the cells and mice exposed to DDAC, and the expression of both the indicator proteins for lamellar body (ABCA3 and Rab11a) and surfactant proteins (A, B, and D) was clearly enhanced. In addition, chronic fibrotic pulmonary lesions were notably observed in mice instilled twice (weekly) with DDAC (500 mug), ultimately resulting in death. Taken together, we suggest that disruption of pulmonary surfactant homeostasis may contribute to DDAC-induced cell death and subsequent pathophysiology and that the formation of lamellar body-like structures may play a role as the trigger. In addition, we propose that the cause of sudden death of mice exposed to DDAC should be clearly elucidated for the safe application of DDAC. |Animals[MESH] |Apoptosis/drug effects[MESH] |Betacoronavirus/*drug effects[MESH] |COVID-19[MESH] |Cell Line[MESH] |Cell Survival/*drug effects[MESH] |Coronavirus Infections/*prevention & control[MESH] |Dose-Response Relationship, Drug[MESH] |Female[MESH] |Gene Expression Regulation/drug effects[MESH] |Humans[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred ICR[MESH] |Pandemics/*prevention & control[MESH] |Pneumonia, Viral/*prevention & control[MESH] |Quaternary Ammonium Compounds/administration & dosage/*toxicity[MESH]Formation of lamellar body-like structure may be an initiator of dide(epmc).pdf DeepDyve Pubget Overpricing