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10.1016/j.antiviral.2020.104899 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2020.104899 32763313!7403104!32763313     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antiviral+Res 2020 ; 182 (ä): 104899 Nephropedia Template TP {{tp|p=32763313|t=2020. Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses |pdf=|usr=}}{{32763313}} gab.com Text Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=32763313 #FOAvip Remdesivir was shown to inhibit RNA-dependent RNA-polymerases (RdRp) from distinct viral families such as from Filoviridae (Ebola) and Coronaviridae (SARS-CoV, SARS-CoV-2, MERS). In this study, we tested the ability of remdesivir to inhibit RdRps from the Flaviviridae family. Instead of remdesivir, we used the active species that is produced in cells from remdesivir, the appropriate triphosphate, which could be directly tested in vitro using recombinant flaviviral polymerases. Our results show that remdesivir can efficiently inhibit RdRps from viruses causing severe illnesses such as Yellow fever, West Nile fever, Japanese and Tick-borne encephalitis, Zika and Dengue. Taken together, this study demonstrates that remdesivir or its derivatives have the potential to become a broad-spectrum antiviral agent effective against many RNA viruses. Twit Text FOAVip Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=32763313 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32763313 #FOAvip English Wikipedia <ref>{{Cite pmid|32763313}}</ref> Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses #MMPMID32763313 Konkolova E; Dejmek M; Hrebabecky H; Sala M; Boserle J; Nencka R; Boura E Antiviral Res 2020[Oct]; 182 (ä): 104899 PMID32763313show ga Remdesivir was shown to inhibit RNA-dependent RNA-polymerases (RdRp) from distinct viral families such as from Filoviridae (Ebola) and Coronaviridae (SARS-CoV, SARS-CoV-2, MERS). In this study, we tested the ability of remdesivir to inhibit RdRps from the Flaviviridae family. Instead of remdesivir, we used the active species that is produced in cells from remdesivir, the appropriate triphosphate, which could be directly tested in vitro using recombinant flaviviral polymerases. Our results show that remdesivir can efficiently inhibit RdRps from viruses causing severe illnesses such as Yellow fever, West Nile fever, Japanese and Tick-borne encephalitis, Zika and Dengue. Taken together, this study demonstrates that remdesivir or its derivatives have the potential to become a broad-spectrum antiviral agent effective against many RNA viruses. |Adenosine Triphosphate/*analogs & derivatives/chemistry/pharmacology[MESH] |Antiviral Agents/chemistry/*pharmacology[MESH] |Betacoronavirus/drug effects/enzymology[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/*drug therapy/*virology[MESH] |Flavivirus/*drug effects/enzymology[MESH] |Humans[MESH] |Inhibitory Concentration 50[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/*virology[MESH] |RNA Viruses/drug effects/enzymology[MESH] |RNA-Dependent RNA Polymerase/*antagonists & inhibitors/metabolism[MESH]Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA (epmc).pdf DeepDyve Pubget Overpricing