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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Monoclon+Antib+Immunodiagn+Immunother 2020 ; 39 (4): 107-111 Nephropedia Template TP
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A Novel Hypothesis for Original Antigenic Sin in the Severe Disease of SARS-CoV-2 Infection #MMPMID32762609
Kohler H; Nara P
Monoclon Antib Immunodiagn Immunother 2020[Aug]; 39 (4): 107-111 PMID32762609show ga
In this hypothesis, we address the biological/immunological pathway leading to severe disease or death after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The underlying immune response is described with "original antigenic sin" (OAS) whereby previous infections influence the response to future virus encounters. We cite evidence for OAS-induced immunopathology in HIV-1 disease. We hypothesize that similar immune abnormalities can occur after infection with SARS-CoV-2. This hypothesis is supported by recent analysis of the antibodies in infected patients demonstrating serological and B cell abnormalities. The concept of symmetrical clonal regulation developed earlier for the immune network illustrates the pathway suggested by our hypothesis and may be helpful to develop strategies avoiding severe coronavirus disease 2019.