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10.1080/07391102.2020.1803965 http://scihub22266oqcxt.onion/10.1080/07391102.2020.1803965 32762537!7484580!32762537     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biomol+Struct+Dyn 2021 ; 39 (17): 6761-6771 Nephropedia Template TP {{tp|p=32762537|t=2021. In silico virtual screening, characterization, docking and molecular dynamics studies of crucial SARS-CoV-2 proteins |pdf=|usr=}}{{32762537}} gab.com Text In silico virtual screening, characterization, docking and molecular dynamics studies of crucial SARS-CoV-2 proteins JO: J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=32762537 #FOAvip The ongoing pandemic COVID-19 (COrona Virus Immuno Deficiency-2019) which is caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome-CoronaVirus-2) has emerged as a pandemic with 400,000 plus deaths till date. We do not have any drug or vaccine available for the inhibition of this deadly virus. The expedition for searching a potential drug or vaccine against COVID-19 will be of massive potential and favor. This study is focused on finding an effective natural origin compound which can put a check on the activity of this virus. We chose important proteins from the SARS-CoV-2 genome such as NSP4, NSP15 and RdRp along-with the human ACE2 receptor which is the first point of contact with the virus. Virtual screening and followed up molecular docking resulted in Baicalin and Limonin as the final lead molecules. 200 ns of MD simulation for each protein-ligand complex provides the insights that Baicalin has a potential to target NSP4, NSP15 and RdRp proteins. Limonin which is largely used in traditional Indian medicine system is found to inhibit the human ACE2 receptor (making it inefficient in binding to the receptor binding domain of SARS-CoV-2). Our studies propose Baicalin and Limonin in combination to be studied in vitro and in vivo against COVID-19.Communicated by Ramaswamy H. Sarma. Twit Text FOAVip In silico virtual screening, characterization, docking and molecular dynamics studies of crucial SARS-CoV-2 proteins ????J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=32762537 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32762537 #FOAvip English Wikipedia <ref>{{Cite pmid|32762537}}</ref> In silico virtual screening, characterization, docking and molecular dynamics studies of crucial SARS-CoV-2 proteins #MMPMID32762537 Alazmi M; Motwalli O J Biomol Struct Dyn 2021[Oct]; 39 (17): 6761-6771 PMID32762537show ga The ongoing pandemic COVID-19 (COrona Virus Immuno Deficiency-2019) which is caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome-CoronaVirus-2) has emerged as a pandemic with 400,000 plus deaths till date. We do not have any drug or vaccine available for the inhibition of this deadly virus. The expedition for searching a potential drug or vaccine against COVID-19 will be of massive potential and favor. This study is focused on finding an effective natural origin compound which can put a check on the activity of this virus. We chose important proteins from the SARS-CoV-2 genome such as NSP4, NSP15 and RdRp along-with the human ACE2 receptor which is the first point of contact with the virus. Virtual screening and followed up molecular docking resulted in Baicalin and Limonin as the final lead molecules. 200 ns of MD simulation for each protein-ligand complex provides the insights that Baicalin has a potential to target NSP4, NSP15 and RdRp proteins. Limonin which is largely used in traditional Indian medicine system is found to inhibit the human ACE2 receptor (making it inefficient in binding to the receptor binding domain of SARS-CoV-2). Our studies propose Baicalin and Limonin in combination to be studied in vitro and in vivo against COVID-19.Communicated by Ramaswamy H. Sarma. |*COVID-19[MESH] |*Molecular Dynamics Simulation[MESH] |COVID-19 Vaccines[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH]In silico virtual screening, characterization, docking and molecular d(epmc).pdf DeepDyve Pubget Overpricing