Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1080/07391102.2020.1803968 http://scihub22266oqcxt.onion/10.1080/07391102.2020.1803968 32762511!7484574!32762511     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biomol+Struct+Dyn 2021 ; 39 (17): 6792-6809 Nephropedia Template TP {{tp|p=32762511|t=2021. In silico investigation of phytoconstituents from Indian medicinal herb Tinospora cordifolia (giloy) against SARS-CoV-2 (COVID-19) by molecular dynamics approach |pdf=|usr=}}{{32762511}} gab.com Text In silico investigation of phytoconstituents from Indian medicinal herb Tinospora cordifolia (giloy) against SARS-CoV-2 (COVID-19) by molecular dynamics approach JO: J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=32762511 #FOAvip The recent appearance of COVID-19 virus has created a global crisis due to unavailability of any vaccine or drug that can effectively and deterministically work against it. Naturally, different possibilities (including herbal medicines having known therapeutic significance) have been explored by the scientists. The systematic scientific study (beginning with in silico study) of herbal medicines in particular and any drug in general is now possible as the structural components (proteins) of COVID-19 are already characterized. The main protease of COVID-19 virus is M(pro) or 3CL(pro) which is a key CoV enzyme and an attractive drug target as it plays a pivotal role in mediating viral replication and transcription. In the present study, 3CL(pro) is used to study drug:3CL(pro) interactions and thus to investigate whether all or any of the main chemical constituents of Tinospora cordifolia (e.g. berberine (C(20)H(18)NO(4)), beta-sitosterol (C(29)H(50)O), coline (C(5)H(14)NO), tetrahydropalmatine (C(21)H(25)NO(4)) and octacosanol (C(28)H(58)O)) can be used as an anti-viral drug against SARS-CoV-2. The in silico study performed using tools of network pharmacology, molecular docking including molecular dynamics have revealed that among all considered phytochemicals in Tinospora cordifolia, berberine can regulate 3CL(pro) protein's function due to its easy inhibition and thus can control viral replication. The selection of Tinospora cordifolia was motivated by the fact that the main constituents of it are known to be responsible for various antiviral activities and the treatment of jaundice, rheumatism, diabetes, etc.Communicated by Ramaswamy H. Sarma. Twit Text FOAVip In silico investigation of phytoconstituents from Indian medicinal herb Tinospora cordifolia (giloy) against SARS-CoV-2 (COVID-19) by molecular dynamics approach ????J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=32762511 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32762511 #FOAvip English Wikipedia <ref>{{Cite pmid|32762511}}</ref> In silico investigation of phytoconstituents from Indian medicinal herb Tinospora cordifolia (giloy) against SARS-CoV-2 (COVID-19) by molecular dynamics approach #MMPMID32762511 Chowdhury P J Biomol Struct Dyn 2021[Oct]; 39 (17): 6792-6809 PMID32762511show ga The recent appearance of COVID-19 virus has created a global crisis due to unavailability of any vaccine or drug that can effectively and deterministically work against it. Naturally, different possibilities (including herbal medicines having known therapeutic significance) have been explored by the scientists. The systematic scientific study (beginning with in silico study) of herbal medicines in particular and any drug in general is now possible as the structural components (proteins) of COVID-19 are already characterized. The main protease of COVID-19 virus is M(pro) or 3CL(pro) which is a key CoV enzyme and an attractive drug target as it plays a pivotal role in mediating viral replication and transcription. In the present study, 3CL(pro) is used to study drug:3CL(pro) interactions and thus to investigate whether all or any of the main chemical constituents of Tinospora cordifolia (e.g. berberine (C(20)H(18)NO(4)), beta-sitosterol (C(29)H(50)O), coline (C(5)H(14)NO), tetrahydropalmatine (C(21)H(25)NO(4)) and octacosanol (C(28)H(58)O)) can be used as an anti-viral drug against SARS-CoV-2. The in silico study performed using tools of network pharmacology, molecular docking including molecular dynamics have revealed that among all considered phytochemicals in Tinospora cordifolia, berberine can regulate 3CL(pro) protein's function due to its easy inhibition and thus can control viral replication. The selection of Tinospora cordifolia was motivated by the fact that the main constituents of it are known to be responsible for various antiviral activities and the treatment of jaundice, rheumatism, diabetes, etc.Communicated by Ramaswamy H. Sarma. |*COVID-19[MESH] |*Plants, Medicinal[MESH] |*Tinospora[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH] |Molecular Dynamics Simulation[MESH]In silico investigation of phytoconstituents from Indian medicinal her(epmc).pdf DeepDyve Pubget Overpricing