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Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Med+Virol 2021 ; 93 (2): 1057-1069 Nephropedia Template TP
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A systematic review and meta-analysis of children with coronavirus disease 2019 (COVID-19) #MMPMID32761898
Cui X; Zhao Z; Zhang T; Guo W; Guo W; Zheng J; Zhang J; Dong C; Na R; Zheng L; Li W; Liu Z; Ma J; Wang J; He S; Xu Y; Si P; Shen Y; Cai C
J Med Virol 2021[Feb]; 93 (2): 1057-1069 PMID32761898show ga
To provide a comprehensive and systematic analysis of demographic characteristics, clinical symptoms, laboratory findings, and imaging features of coronavirus disease 2019 (COVID-19) in pediatric patients. A meta-analysis was carried out to identify studies on COVID-19 from 25 December 2019 to 30 April 2020. A total of 48 studies with 5829 pediatric patients were included. Children of all ages were at risk for COVID-19. The main illness classification ranged as: 20% (95% confidence interval [CI]: 14%-26%; I(2) = 91.4%) asymptomatic, 33% (95% CI: 23%-43%; I(2) = 95.6%) mild and 51% (95% CI: 42%-61%; I(2) = 93.4%) moderate. The typical clinical manifestations were fever 51% (95% CI: 45%-57%; I(2) = 78.9%) and cough 41% (95% CI: 35%-47%, I(2) = 81.0%). The common laboratory findings were normal white blood cell 69% (95% CI: 64%-75%; I(2) = 58.5%), lymphopenia 16% (95% CI: 11%-21%; I(2) = 76.9%) and elevated creatine-kinase MB 37% (95% CI: 25%-48%; I(2) = 59.0%). The frequent imaging features were normal images 41% (95% CI: 30%-52%; I(2) = 93.4%) and ground-glass opacity 36% (95% CI: 25%-47%; I(2) = 92.9%). Among children under 1 year old, critical cases account for 14% (95% CI: 13%-34%; I(2) = 37.3%) that should be of concern. In addition, vomiting occurred in 33% (95% CI: 18%-67%; I(2) = 0.0%) cases that may also need attention. Pediatric patients with COVID-19 may experience milder illness with atypical clinical manifestations and rare lymphopenia. High incidence of critical illness and vomiting symptoms reward attention in children under 1 year old.